摘要
长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度超过200个核苷酸的非编码RNA1,因缺乏完整的开放阅读框而不能编码任何蛋白质。在人类基因组中,lncRNA在表观遗传学调控、转录调控与转录后调控等方面发挥着重要作用,已成为继microRNA之后的又一研究热点。lncRNA在肿瘤中的异常表达常发挥不同的生物学作用,表现为癌基因或抑癌基因的特点,可促进或抑制肿瘤的生长。肺癌是一种常见的恶性肿瘤,5年生存率只有17%。本研究通过文献发现lncRNA MALAT1、H19、lincRNA p21、UCA1、BC200与肺癌的发生发展有密切关系,可促进肺癌生长、侵袭转移、细胞凋亡和诱导药物抵抗等。因此本文就上述五种lncRNA在肺癌中的功能及机制进行综述,旨在为肺癌的临床诊断、治疗及预后提供帮助。
Long non-coding RNAs （lncRNAs） are non-coding RNAs that have transcript lengths exceeding 200 bp and do not have the capacity for protein coding because of having no open reading frame. In the human genome, lncRNAs play important regulato-ry roles in the process of epigenetic, transcription and post-transcription, so they have become the focus of research followed by mi-croRNAs. The abnormal expression of lncRNAs in cancer usually represents different functions, such as the function of oncogenes or tumor suppressor genes, which promote or inhibit tumor growth. Lung cancer is a common malignant tumor with a five-year survival rate of 17%. Previous literature shows that MALAT1, H19, lincRNA p21, UCA1, and BC200 are closely related to the development of lung cancer. They could promote cancer growth, invasion and metastasis, apoptosis and induce drug resistance, and so on. This review aims to provide assistance in the diagnosis, treatment, and prognosis of lung cancer by clarifying the functions and mechanisms of ln-cRNAs.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第23期1473-1476,共4页
Chinese Journal of Clinical Oncology
