摘要
目的:研究不同转移模式的ⅢC期卵巢上皮性癌的临床病理特征及预后影响因素,为卵巢上皮性癌临床分型及个体化的治疗提供依据。方法:对1997年1月至2009年12月中山大学肿瘤防治中心收治的91例曾接受腹膜后淋巴结切除术的ⅢC期卵巢上皮性癌患者的临床资料进行回顾性分析,依照转移部位分为腹腔转移组(22例)、淋巴结转移组(12例)和混合型组(57例)。分析各组临床病理因素及治疗方法对预后的影响及其与转移类型的关系。结果:①3种转移类型间年龄、腹水细胞学情况比较,差异有统计学意义(P=0.043;P=0.015),出现淋巴结转移的患者多为50岁以下,存在腹膜转移的患者腹水细胞学阳性率高,未发现各种转移类型之间存在其他临床病理因素的差异。②3种转移类型中5年生存率、总生存时间及无进展生存时间等指标均提示淋巴结转移型预后好于其余2组,但仅无进展生存时间各组间比较差异有统计学意义(P=0.035)。结论:3种不同转移类型的FIGOⅢC期卵巢上皮性癌有一定的异质性(年龄及腹水细胞学),淋巴结转移型的ⅢC期卵巢上皮性癌预后好于腹腔转移病例。
Objective：To investigate the clinicopathological characters and prognostic factors of stage Ⅲ C epithelial ovarian cancer with the different metastatic modes, and to provide the theoretical basis of individual ized treatment of epithelial ovarian cancer. Methods：Clinical data of 91 patients with stage Ⅲ C epithelial o varian cancer treated in Sun Yat-sen University Cancer Center from January 1997 to December 2009 were retrospectively analyzed. All the 91 patients underwent retroperitoneal lymph node dissection to verify or ex clude subclinical lymph node metastasis. According to the matastasis mode,the cases were divided into peri toneal metastasis group（22 cases）, lymph nodes metastasis group （12 case） and mixed metastasis （both peritoneal and lymph node metastasis）group（57 cases）. The relationship between clinicopathologicaL factors and prognosis and relationship between clinicopathological factors and metastatic types was analyzed. Re sults.①There were significant difference in age and peritoneal cytology among the three groups with differ ent metastasic types （P =0. 043 and 0. 015 respectively）. No other clinicopathological factors was found dif ferent among the three groups（ all P 〉 0.05）. ②Lymphnode metastasis group revealed to have a better prog nosis than the other two groups in the 5-year survival rate,overall survival and progression-free survival how ever the differences were not significant, only the progression-free survival showed significantly different a mong the three groups （ P = 0. 035）, Conclusions. There is heterogeneity in the three metastatic types of stage ⅢC epithelial ovarian cancer,the prognosis of patients with lymph nodes metastasis is better than that of patients with peritoneal metastasis.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2013年第12期921-924,共4页
Journal of Practical Obstetrics and Gynecology
基金
国家高科技研究发展计划(863计划)(编号:2012AA02A507)
关键词
卵巢恶性肿瘤
上皮性
ⅢC期
腹腔转移
淋巴结转移
Ovarian Cancer
Epithelial
Stage Ⅲ C
Peritoneal metastasis
Lymphnode metastasis
