摘要
目的 探讨3.0T磁共振磁敏感加权成像（SWI）和灌注加权成像（PWI）在反映胶质瘤血管生成中的应用价值。方法 经手术病理证实的胶质瘤35例，其中低级别胶质瘤16例（WHOⅠ~Ⅱ级），高级别胶质瘤19例（WHOⅢ~Ⅳ级）。所有病例均接受常规序列、SWI及PWI扫描，并获得SWI图和脑血容量（CBV）彩图，逐层观察SWI图胶质瘤静脉分布情况，并按静脉多少进行评分。利用CBV彩图观测胶质瘤实质相对CBV（rCBV）值，并对肿瘤静脉及肿瘤实质rCBV值行相关性分析。结果 低级别胶质瘤静脉评分：0分11例（68.75%），1分5例（31.25%）；高级别胶质瘤静脉评分：1分3例（15.79%），2分16例（84.21%），胶质瘤静脉评分差异有统计学意义（P〈0.001）。低、高级别胶质瘤肿瘤实质rCBV值分别为2.250.32、5.800.75（P〈0.001）。胶质瘤实质rCBV值与静脉评分在同一病理级别胶质瘤中有明显相关性（r=0.727，P〈0.001）。结论 SWI技术为在活体上从磁共振功能影像学角度反映胶质瘤血管生成情况提供了一个新视角，在胶质瘤的诊断评价中有重要参考价值。
Objective To observe the value of 3.0T MR SWI on reflecting tumor angiogenesis of glioma using SWI and PWI. Methods Totally 35 cases of glioma confirmed pathologically, including 16 of low-grade glioma （WHOⅠ—Ⅱgrade） and 19 of high-grade glioma （WHO Ⅲ— Ⅳgrade） were enrolled. All patients underwent routine MR series as well as SWI and PWI scanning, and SWI image and CBV color image were obtained. SWI images were observed layer by layer, and veins within glioma were scored. rCBV value of glioma was counted from CBV color images, and correlation of tumor vein with tumor rCBV value was analyzed. Results Among 16 cases of low-grade glioma, the score of tumor vein was 0 point in 11 cases （11/16, 68.75%） and 1 point in 5 cases （5/16, 31.25%）. Among 19 cases of high-grade glioma, the score of tumor vein was 1 point in 3 cases （3/19, 15.79%） and 2 points in 16 cases （16/19, 84.21%, P〈0.001）. rCBV value of low and high grade glioma was 2.250.32 and 5.800.75, respectively （P〈0.001）. rCBV value had positive correlation with tumor vein scoring among the same pathological grade gliomas （r=0.727, P〈0.001）. Conclusion SWI can reflect tumor angiogenesis in vivo from different view of functional MR imaging, which plays an important role in grading diagnosis of glioma.
出处
《中国医学影像技术》
CSCD
北大核心
2013年第12期1937-1940,共4页
Chinese Journal of Medical Imaging Technology
关键词
胶质瘤
灌注成像
磁敏感加权成像
Glioma
Perfusion imaging
Susceptibility-weighted imaging
