摘要
目的:评价经阴道二维超声进行卵巢窦卵泡计数(antral follicle counts,AFC)观察者间结果的一致性。方法:两名观察者通过经阴道超声对51名不孕女性患者于月经周期的卵泡早期计数窦卵泡。用二维超声进行AFC,并记录所用时间;存储每个卵巢的三维信息,后续通过多平面模式计数窦卵泡。记录三维超声每个步骤所用的时间,计算出总时间。通过组内相关系数(intraclass correlation coefficients,ICC)和Bland-Altman图的一致性限度(limits of agreement,LOA)来评估两种计数方法的可靠性。结果:二维超声和三维超声计数窦卵泡的平均值差异无统计学意义,分别为(18.63±11.39)个和(18.73±11.41)个。三维超声的ICC优于二维超声;三维超声的ICC:平均值0.994,95%可信区间(0.990,0.997);二维超声的ICC:平均值0.979,95%可信区间(0.963,0.988),P<0.01。Bland-Altman图中,三维超声的LOA比二维超声范围小,分别为(-3.46,3.35)和(-6.78,6.31);而三维超声所用的总时间比二维超声长得多,分别为(204.0±53.0)s和(112.4±34.8)s,P<0.001;但受试者的暴露时间三维超声要远远短于二维超声,分别为(48.0±7.5)s和(112.4±34.8)s,P<0.001。结论:三维超声明显改善了窦卵泡计数的观察者间的可靠性,却增加了计数总时间,但与实时二维超声相比,大大缩短了受试者检查暴露的时间。
To assess the interobserver reliability of antral follicle counts （AFC） using real-time two-dimensional （2D） ultrasound and three-dimensional （3D） ultrasound. Methods： Two observers conducted transvaginal ultrasound examinations in 51 subfertile women in the early follicular phase of the menstrual cycle. Antral follicles were counted using real-time 2D ultrasound and the time taken was recorded. A 3D volume was then acquired from each ovary and stored for subsequent offline analysis using the multiplanar view. The time taken for each step was recorded and the total time was calculated. Intraclass correlation coefficients （ICC） and limits of agreement were used to assess the reliability. Results： There was no difference in the mean antral follicle counts using real-time 2D （18.63±11.39） and 3D （18.73±11.74） ultrasound. According to the ICC, there was a significantly higher interobserver reliability for counts made using 3D （mean, 0.994; 95% CI, 0.990-0.997） as compared with real-time 2D ultrasound （mean, 0.979; 95% CI, 0.963-0.988）, P〈0.01. 3D ultrasound was also associated with narrower limits of agreement （-3.46, 3.35） than was 2D ultrasound （-6.78, 6.31）. While the total time taken was significantly longer for the 3D technique [（204.0±53.0） s vs. （112.4±34.8） s, P〈0.001], the time required for the actual ultrasound examination was significantly less [（48.0±7.5） s vs. （112.4±34.8） s, P〈0.001].Conclusion： 3D ultrasound significantly improves the interobserver reliability of antral follicle counts. While this is at the expense of time overall, the duration of the actual ultrasound examination and the patient exposure is significantly reduced using 3D compared with real-time 2D ultrasound.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2013年第6期896-900,共5页
Journal of Peking University:Health Sciences
关键词
超声检查
成像
三维
卵泡
观察者偏差
Ultrasonography, Imaging, three-dimensional, Ovarian follicle, Observer variation
