摘要
【目的】 研究2 3 5U脑内照射对新生大鼠生长发育的影响。 【方法】 新生大鼠 ( <2 4h)于侧脑室单次注入 2 μl不同浓度的2 3 5U ,各组大鼠的浓度分别为 0、1、5、10 μg ,观察α射线对新生大鼠早期生长发育的影响。 【结果】 在研究组中 ,体重增长的下降最为明显 ,与对照组相比有显著性差异 ;脑重 /体重的比值、张耳、体毛生长、萌牙时间在各组中无明显差异 ;而开眼时间、游泳运动在不同剂量照射组中均有延迟 ,并与剂量相关。 【结论】 新生大鼠脑内照射2 3 5U后可导致生长发育的迟缓。
Objective Effects of cerebrum exposure to alpha irradiation from radionuclide 235 U on physical growth and development of neonatal rats were studied. Methods Neonatal rats were irradiated with one single injecting 2μl alpha radionuclide from 235 U into the left lateral ventricle of the rat brain at postnatal 1(<24h) at a dose of 0、1、5、10μg of 235 U,respectively.These rats were observed for the early physical growth and development. Results In the irradiation group,weight increase was lower and different significantly from those in the controls.Of groups there were not statistically in the radio of brain weight/body weight,body hair sprouted,pinna erected,incisor eruption.The retardation in irradiation group was found and different significantly from those in the controls such the age of acquisition in physiologic markers as eye opening,movement and coordination function and activty as swimming.For most parameters there was a dose dependent effect. Conclusions The neonatal rats having cerebrum exposure to alpha irradiation by 235 U showed delayed growth and abnormal development.
出处
《中国儿童保健杂志》
CAS
2000年第6期388-390,共3页
Chinese Journal of Child Health Care
基金
国家自然科学基金资助项目!NO39470 389
