摘要
目的了解中国部分艾滋病抗病毒治疗定点医院住院艾滋病患者的死亡原因及其相关影响因素。方法在7所省级艾滋病抗病毒治疗定点医院收集2009--2010年艾滋病住院死亡患者的死因及相关医疗信息，采用CoDe编码系统归类，应用logistic回归分析患者是否死于艾滋病相关原因的影响因素。结果7所医院共收集381例艾滋病患者的临床医疗及死因信息，患者以男性为主（82．4％），30～45岁占多数，生前曾接受抗病毒治疗（ART）者占32．3％。252例（66．1％）死于艾滋病相关原因，其中机会性感染占92-4％，以结核菌、肺孢子菌、马尔尼菲青霉菌感染为主。在非艾滋病相关死亡原因中，前三位依次是非艾滋病相关感染、肝炎、非艾滋病相关肿瘤，分别占29．5％、22，5％、10．1％。患者死亡前一年内有注射吸毒行为、未接受ART、合并机会性感染、未合并肝炎及死亡前最近一次CD4＋T淋巴细胞计数水平较低的病例，死于艾滋病相关原因的风险较高。结论机会性感染、非艾滋病相关感染、肝炎是艾滋病患者最主要的前三位死因，接受ART的患者死于非艾滋病相关原因的风险低于未接受ART者，且治疗时间越长，死于非艾滋病相关原因的比例越低。
Objective In this study, researchers investigated the demographic and clinical characteristics of AIDS patients who died in hospitals, analyzed the specific causes of death, and looked for the correlation between specific cause of death and their clinical characteristics. Methods Data of clinical characteristics of patients and their specific causes AIDS of death who died in the seven hospitals from 2009 to 2010 were collected retrospectively. All the specific causes of death were classified according to the Cause of Death （CoDe） project protocol. Univariate analysis and multivariate logistic regression analysis were used to find the association between some categorical variables and the risk for AIDS patients died from AIDS related illnesses. Results Clinical characteristics and the cause of death of the 381 deceased in seven hospitals in this study were collected. 82.4% were male, with priority as 30-45 years old. 123 （32.3%） death patients had received ART before death. In all death cases, the cause of death of 252 patients （66.1%） were due to AIDS related diseases, with opportunistic infections the most （92.4%）. Tubercle bacillus, infection of Penicillium marneffei and Pneumocystis jirovecy were the three leading causes of opportunistic infection deaths. Of 129 patients who died of non-AIDS related disease, non-AIDS infection （29.5%）, hepatitis （22.5%）, and non-AIDS malignancy （10.1%） were the first three causes of death. The cause of death in patients who had injecting drug use behavior within one year, had not receivied ART or not long enough, with opportunistic infections, without hepatitis, with the last low CD, cell counts before death etc. were tend to due to AIDS related disease. Conclusion Opportunistic infections, non-AIDS related infections and hepatitis were the three leading causes of death in this study. The duration of time on ART had impact on the patient＇ s cause of death. The HIV infected patients who had received ART before death had more risk to die of non-AIDS related disease, compared to patients who had not. The longer time they had accessed to ART, the less likely they would die on non-AIDS related illnesses.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2013年第12期1237-1241,共5页
Chinese Journal of Epidemiology
关键词
艾滋病
死亡原因
相关疾病
抗病毒治疗
AIDS
Cause of death
Related disease
Antiretroviral therapy
