摘要
目的系统评价不同种族（尤其亚洲人群）血浆凝血因子Ⅶ（FⅦ）基因高变区4（HvR4）多态性与冠心病的相关性。方法计算机检索中国生物医学文献数据库（CBM）、维普中文科技期刊全文数据库（VIP）、中国期刊全文数据库（CNKI）、万方数据库、PubMed、Embase、CochraneLibrary等，检索时间从建库至2013年4月30日，收集所有凝血因子Ⅶ基因HVR4位点多态性与冠心病相关的病例对照研究。根据纳入排除标准选择符合的文献，评价纳入研究的质量并提取资料，采用RevMan5．1软件与Stata11．0软件进行Meta分析。结果共纳入14篇文献15项研究，包括冠心病3167例，对照3168例。FⅦ基因HVR4位点基因多态性与冠心病的相关性Meta分析结果显示，H7等位基因与H6＋H5等位基因对比（OR=O．86，95％CI：0．77～0．96，P=0．005）、基因型H7H7与H6H6＋H7H6对比（OR=0．77，95％CI：0．67—0．89，P=0．0005），发现携带H7等位基因与H7H7基因型人群发生冠心病的风险低，差异有统计学意义；H6等位基因与H7＋H5等位基因对比（OR=1．17，95％CI：1．09。1．26，P〈0．0001），携带H6等位基因人群发生冠心病的风险增加，差异有统计学意义；而携带H5等位基因与H7＋H6等位基因人群发生冠心病风险的差异无统计学意义（OR=1．20，95％CI：0．76。1．90，P----0．43）。结论Meta分析结果显示，不同种族人群中FⅦ基因HVR4位点H7等位基因与H7H7基因型很可能为冠心病的保护性因素，亚洲人群较欧洲人群相比，H7等位基因及H7H7基因型与冠心病低风险相关性更强。H6等位基因可能为冠心病的危险因素，而H5等位基因与冠心病易感性关联不大。
Objective To assess the correlation between polymorphisms in the coagulation factor VII （F VII ） gene hypervariable region 4 （HVR4） site and risk related to coronary heart disease （CHD） in different ethnic populations, especially the Asian populations. Methods Publications up to April 2013, from CBM, CNKI, Wanfang Database, VIP, PubMed, Cochrane Library and Embase were searched to collect data from case-control studies related to F VII gene HVR4 site and CHD in populations from different ethnicities. Quality of studies was evaluated, available data extracted and both RevMan 5.1 and Stata 11.0 softwares were used for Meta-analysis. Results Fifteen case-control studies were included, involving 3167 cases with CHD group and 3168 cases in the control group. Results on this Meta-analysis showed that： a） polymorphism of the F VU gene HVR4 site H7/H6＋ H5 and CHD, b） H7H7/H6H6 ＋ H7H6 and CHD were both slightly correlated between people with different ethnic backgrounds. However, the H6 allele versus H7 ＋ H5 allele and CHD showed different results--a high correlation seen in different ethnic groups. H5 allele versus H6 ＋ H7 allele and CHD did not appear significant difference（OR= 1.20,95%CI： 0.76-1.90,P=0.43）. Conclusion Both FV~ gene HVR4 polymorphisms H7 allele and the H7H7 genotype might have served as protective factors for CHD in different ethnic groups, H6 allele might serve as a risk factor for CHD, but H5 allele was likely not to be associated with CHD in different ethnic groups.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2013年第12期1250-1254,共5页
Chinese Journal of Epidemiology
关键词
冠心病
基因多态性
凝血因子Ⅶ基因高变区4
META分析
Coronary artery disease
Polymorphisms
Blood coagulation factors VII gene hypervariable region 4
Meta-analysis
