摘要
β淀粉样蛋白(β-amyloid peptide,Aβ)在脑组织中聚集和沉积,启动了阿尔茨海默病(Alzheimer's disease,AD)的病理过程。因此,促进Aβ清除,是防治阿尔茨海默病的重要靶点之一。研究证明一些中药复方及提取物能影响淀粉蛋白降解酶的活性,血脑屏障的转运及小胶质细胞的吞噬,促进Aβ清除,改善阿尔茨海默病动物模型的记忆和学习。该文综述了Aβ与阿尔茨海默病关系,Aβ清除机制以及中药对Aβ清除作用。
Aggregation and accumulation of β-mnyloid peptide （Aβ） in brain tissues contribute to the pathogenesis of Alzhei- mer＇s disease. Therefore, the promotion of Aβ clearance is one of the key targets for preventing and treatment Alzheimer＇s disease. Studies proved that some traditional Chinese medicine（TCM） compounds and extracts could impact the activity of degrading enzyme in amyloid peptide, the transport of hemato encephalic barrier and the phagocytosis of microglial cells, promote Aβ clearance, and im- prove learning and memory of animal models with Alzheimer＇s disease. In this review, we made an summary for the relations between Aβ and Alzheimer＇s disease, the Aβ clearance mechanism and the clearance effect of traditional Chinese medicines.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第23期4020-4023,共4页
China Journal of Chinese Materia Medica
基金
国家重大财政专项(1981020421)
广东省产业技术研究与开发项目(2011B010500004)
关键词
中药
Aβ淀粉样蛋白
清除
traditional Chinese medicine
β-amyloid peptide
clearance
