摘要
目的探讨肺癌血清B7-H4与肺癌的CT征象及病理类型之间的相关性。方法回顾分析经病理确诊的74例肺癌患者的CT表现和血清B7-H4检测结果。结果肺癌患者中鳞癌、腺癌血清B7-H4水平为(46.61±4.48)μg/L、(44.76±3.78)μg/L,与肺良性疾病患者血清B7-H4水平(29.52±4.85)μg/L比较,差异有统计学意义(t值分别为15.5805、12.7966,均P<0.01);Ⅲ~Ⅳ期肺癌患者血清B7-H4水平(46.16±4.27)μg/L,显著高于Ⅰ~Ⅱ期患者(41.62±5.01)μg/L(t=4.1343,P<0.01)。按鳞癌联系强度依次为毛刺征、分叶征、空泡征、细支气管充气征、胸膜凹陷征;按腺癌联系强度依次为毛刺征、分叶征、细支气管充气征、胸膜凹陷征、空泡征。结论 CT联合应用血清B7-H4检测结果,可进一步提高肺癌诊断的准确率及检出率。
Objective To evaluate the correlations among CT signs,pathological type and the serum levels of B7-H4 for the lung cancer. Methods Retrospective analysis was made for the CT signs and serum levels of B7-H4 of 74 pathologically confirmed cases of patients with lung cancer. Results Serum levels of B7-H4 in squamous carcinoma and adenocareinoma respectively were（46. 61 ± 4. 48 ）ug/L and（ 44. 76 ＋ 3.78） p^g/L, whereas, the serum level of B7-H4 in benign lung disease was （ 29. 52 ± 4. 85 ） ug/L, with statistical signifieanees（ t = 15. 5805 ,P 〈 0. 01 ; t = 12. 7966, P 〈 0. 01 ）. Serum level of B7-H4 in patient of phase m-w （ 46. 16±4. 27） ug/L was significantly higher than that of phase I - Ⅱ （41.62±5.01 ） ug/L, with statistical significance （ t = 4. 1343, P 〈 0. 01 ）. The imaging findings were spiculation, lobulation, voeule sign, air bronchgram and pleural indentation according to the associations with squamous carcinoma. The imaging findings were spiculation, lobulation, air bronchgram, pleural indentation and voeule sign according to the associations with adenoearcinoma. Conclusions Combined application of thoracic CT, pathology and the serum levels of B7-H4 could improve the diagnostic accuracy and detection rate of lunz cancer.
出处
《中华消化病与影像杂志（电子版）》
2013年第5期5-8,共4页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
