摘要
目的:筛选天麻素经鼻给药制剂的吸收促进剂种类和用量。方法:采用HPLC测定天麻素含量,流动相乙腈-0.05%磷酸(3∶97),检测波长220 nm。采用Franz水平扩散池,以家兔鼻黏膜为渗透屏障,比较冰片、丙二醇、水溶性氮酮对天麻素经鼻给药制剂的促渗透效果,确定吸收促进剂种类和用量。结果:3种吸收促进剂均对天麻素经鼻给药制剂有促渗作用,5.0%水溶性氮酮的促渗效果最好,3 h内天麻素累积渗透量达3 470.54μg·cm-2,增渗倍数1.922。结论:5%氮酮可作为天麻素经鼻给药制剂的吸收促进剂。
Objective： To screen out species and amounts of absorption enhancer for intranasal administration preparations of gastrodin. Method： The content of gastrodin was determined by HPLC with mobile phase of acetonitrile-0.05% phosphoric acid（3：97） and detection wavelength at 220 nm.Improved Franz-type diffusion cell was adopted,with rabbit nasal mucosa partition as transdermal barrier,single factor tests were used to compare promoting penetration effect of borneol,propylene glycol and water-soluble azone on intranasal administration preparations of gastrodin,in order to determine kinds and amounts of absorption enhancer. Result： All of three absorption enhancers had promoting penetration effect on intranasal administration preparations of gastrodin,but 5% water-soluble azone was the best one,its cumulative permeation quantity was 3 470.54 μg·cm-2 in 3 h,enhancement ratio was 1.922. Conclusion： 5% Water-soluble azone could be as a absorption enhancer for intranasal administration preparations of gastrodin.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第24期25-28,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省科研院所科技成果转化项目(10010118)
关键词
天麻素
经鼻给药制剂
吸收促进剂
冰片
丙二醇
水溶性氮酮
gastrodin
intranasal administration preparations
absorption enhancer
borneo1
propylene glycol
water-soluble azone
