摘要
目的研制酒石酸美托洛尔渗透泵控释片,对处方及工艺进行筛选并评价其体外释药行为。方法对处方及工艺采用单因素考察方法进行筛选,然后采用正交试验方法,对处方进行优化。结果所制备的酒石酸美托洛尔渗透泵控释片,工艺重现性较好;羟丙甲纤维素(HPMC)K15m的用量、PEG4000的用量和包衣增重对渗透泵片释放速率有明显的影响;所制备的酒石酸美托洛尔渗透泵控释片在12 h内有明显的零级释药特征。结论此种处方工艺简单易行,体外释药曲线平稳恒定,可以克服和改善目前该普通制剂在临床应用方面的缺点和不足。
Objective To develop metoprolol tartrate osmotic pump tablets, prescription and proces^e~ for screening and evaluation of the in vitro release behavior. Methods The prescription and craft, and then using orthogonal experiment method to optimize the prescription. Results Metoprolol tartrate prepared as osmotic pump tablets, better process reproducibility; hydroxypropyl methyl cellulose （HPMC） K15M the dosage, PEG4000 dosage and coating weight gain of the release rate of the osmotic pump tablets significant impact; metoprolol tartrate prepared as osmotic pump tablets within 12 hours zero-order release characteristics. Conclusion Such prescription is a simple technique, stable in vitro release curve is constant, the ordinary preparations in clinical application of the shortcomings and deficiencies can be overcome and improve.
出处
《中国卫生产业》
2013年第30期16-18,共3页
China Health Industry
关键词
酒石酸美托洛尔
渗透泵控释片
片剂
Metoprolol tartrate
Osmotic pump controlled release tablet
Tablets
