摘要
目的 :研究慢性肾功能不全长期进程及其肾功能改变 ,并提供可靠的定量形态学依据。方法 :应用光镜、电镜半薄、超薄连续切片和体视学定量分析方法 ,对锂导致大鼠慢性肾功能不全的肾小球结构进行了定量形态学分析。结果 :锂导致大鼠慢性肾功能不全的肾小球最明显的改变是肾小球平均体积减小 ,且个体动物内肾小球大小差异很大 ;肾小球毛细血管有效滤过表面积减少 ,并且与肌酐清除率之间有明显的相关性。结论
Objective:Administration of lithium to newborn rats causes renal inefficiency.methods:To determine the spontaneous course of chronic renal inefficiency and provide morphological basis for renal functional research.The present study deals with light and electron microscopic quantitative measurements of glomerular changes in this animal model.Results:The most marked glomerular change in lithium treated rats was decreased mean glomerular volume and increased variation in glomerular size in a individual.Conclusion:Furthermore filtration surface per glomerulus showed significant correlation with inulin clearance.Decrease in clearance was associated with remnan filtration surface.
出处
《锦州医学院学报》
2000年第5期5-8,共4页
Journal of Jinzhou Medical College
基金
辽宁省自然基金资助课题
关键词
慢性肾功能不全
锂
肾小球
chronic renal inefficiency
lithium
glomerulus
