摘要
目的:评价细胞因子诱导的杀伤细胞(CIK)联合化疗治疗晚期卵巢癌的疗效、不良反应及对患者生活质量的影响。方法:将68例晚期卵巢癌患者随机分为单纯化疗组37例,给予TC(紫杉醇+卡铂)方案化疗,每3周重复;联合治疗组31例,于化疗的基础上再予以CIK细胞治疗,至少2周期后评价疗效,观察疗效、免疫功能、不良反应及生活质量。结果:治疗2个疗程后,联合治疗组患者外周血CD3+、CD4+/CD8+水平明显高于单纯化疗组,差异有统计学意义(P<0.05)。两组患者疾病控制率分别为75.6%和87.1%,差异有统计学意义(P<0.05),联合治疗组患者较单纯化疗患者PFS延长2.5个月。联合治疗组患者生活质量改善情况优于单纯化疗组,两组卡氏评分下降百分比比较差异有统计学意义(P<0.05)。联合治疗组患者血红蛋白、白细胞、血小板的损害均低于单纯化疗组,差异有统计学意义(P<0.05)。结论:CIK细胞联合化疗治疗晚期卵巢癌可提高疗效及疾病控制率,其综合治疗效果明显优于单纯化疗组。
Objective： To evaluate the curative effect and adverse reactions of cytokine - induced killer （CIK） cells combined with chemotherapy in treatment of advanced ovarian cancer and the impact on quality of life （QOL） of patients. Methods.. Sixty - eight patients with advanced ovarian cancer were randomly divided into simple chemotherapy group （37 patients） and combined treatment group （31 pa- tients）, the patients in simple chemotherapy group were treated with TC protocol, three weeks were designed as one course of treatment; while the patients in combined treatment group were treated with CIK cells and chemotherapy; after at least two courses of treatment, the curative effects were evaluated; the curative effects, immune functions, adverse reactions, and QOLs in the two groups were observed. Results： After two courses of treatment, the levels of CD3 ＋ and CD4＋/CD8 ＋ in peripheral blood of combined treatment group were statistically signif- icantly higher than those in simple chemotherapy group （P 〈0.05） ; the disease control rates in the two groups were 75.6% and 87.1%, respectively, there was statistically significant difference between the two groups （P 〈 0.05）, progression - free - survival （PFS） in com- bined treatment group was longer than that in simple chemotherapy group by 2. 5 months; the improvement of AOL in combined treatment group was superior to simple chemotherapy group, there was statistically significant difference in the percentage of decrease of Karnofsky score between the two groups （P 〈 0. 05） ; the decreasing amplitudes of hemoglobin, white blood cells and platelet in combined treatment group were statistically significantly lower than those in simple chemotherapy group （P 〈 0. 05） .
出处
《中国妇幼保健》
CAS
北大核心
2013年第35期5898-5901,共4页
Maternal and Child Health Care of China
关键词
晚期卵巢癌
CIK细胞
化学治疗
Advanced ovarian cancer
Cytokine- induced killer cell
Chemotherapy
