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促B淋巴细胞成熟蛋白1及其与淋巴瘤发病关系的研究进展 被引量：3

Research progress on B Lymphocyte-induced Maturation Protein 1 and Its Relationship with the Development of Lymphoma——Review
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摘要 大量研究显示,促B淋巴细胞成熟蛋白1(B lymphocyte-induced maturation protein 1,Blimp 1)作为一种转录抑制因子,在B细胞向浆细胞分化的终末阶段起着重要的作用。Blimp 1转录因子的异常在淋巴瘤的形成及发展中起着重要作用。本综述介绍并总结了Blimp 1蛋白的结构及其功能、它在B细胞发育中的作用、它的主要靶基因及其发挥转录抑制功能的机制。此外,本文还将Blimp 1的转录异常与弥漫性大B细胞淋巴瘤(DLBCL)的关系进行了初步总结。 Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 （ Blimp 1 ） is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1 ＇s protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
作者 刘之茵 李军民
机构地区 上海交通大学医学院附属瑞金医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2013年第6期1623-1626,共4页 Journal of Experimental Hematology
关键词 B淋巴细胞成熟蛋白1 转录因子 细胞分化 基因突变 弥漫性大B细胞淋巴瘤 B lymphocyte-induced maturation protein 1 transcription factor cell differentiation gene mutation diffuse large B cell lymphoma
分类号 R733.1 [医药卫生—肿瘤]
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参考文献38

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二级参考文献33

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中国实验血液学杂志
2013年 第6期

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