期刊文献+

手性固定相-高效液相色谱法分离噁唑菌酮对映异构体 被引量:1

Resolution of Enantiomers of Famoxadone by HPLC with Chiral Stationary Phase
下载PDF
导出
摘要 采用Kromasil celluCoat手性色谱柱(4.6mm×250mm,5μm)作为分离柱,用高效液相色谱法对噁唑菌酮对映异构体进行了拆分。在优化的试验条件下,正己烷-乙醇(70+30)混合液为流动相,流量为1.0mL·min-1,柱温为25℃,噁唑菌酮对映异构体在10min内成功分离。 A method of HPLC was proposed for the resolution of enantiomers of famoxadone using Kromasil cellucoat chiral column (4. 6 mm× 250 mm, 5μm) as separation column. A mixture of n-hexane and ethanol (70+ 30) was used as mobile phase with a flow-rate of 1.0 mL · min^-1. Column temperature of 25 ℃ was chosen. Under the optimized conditions, enantiomers of famoxadone were successfully separated within 10 min.
出处 《理化检验(化学分册)》 CAS CSCD 北大核心 2013年第12期1483-1485,共3页 Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
关键词 噁唑菌酮 高效液相色谱法 手性固定相 对映异构体 Famoxadone HPLC Chiral stationary phase Enantiomers
  • 相关文献

参考文献14

  • 1WILLIAMS A. Opportunities for chiral agrochemicals [J]. Pesticide Science, 1996,46(1):3-9.
  • 2ELLINGTON J J, ENANNS J. High-performance liq- uid chromatographic separation of the enantiomers of organophosphorus pesticides on polysaccharide chiral stationary[J]. Journal of Chromatography A, 2001, 928(1) : 145-154.
  • 3I.IU Wei-ping, GAN J, SCHLENK D, et al. Enanti- oselectivity in environmental safety of current chiral in- secticide[J]. Proceedings of the National Academy of Sciences, 2005,102 : 701-706.
  • 4LIU Wei-ping, GAN J, QIN Su-jie. Separation and a quatic toxicity of enantiomers of synthetic pyrethroid insecticides[J]. Chirality, 2005,17:127-133.
  • 5OCKENFELS H, KOHLER F, MEISE W. Terato- genic effect and stereospecificity of a thalidomide me- tabolite[J ]. Pharmazie, 1976,31:492-493.
  • 6WU Y S, LEE H K, LI S F. High-performance chiral separation of fourteen triazole fungicides by sulfated β- cyclodextrin-mediated capillary electrophoresis [ J ]. Journal of Chromatography A, 2001,912 : 171-179.
  • 7利健文.毛细管电泳手性拆分美托洛尔、阿普洛尔和卡替洛尔对映体[J].理化检验(化学分册),2010,46(2):175-177. 被引量:4
  • 8TORIBIO L, NOZAL M J. Chiral separation of some triazole pesticides by supercritical fluid chromatogra- phy[J]. Journal of Chromatography A, 2004, 1046: 249-253.
  • 9LIU Wei-ping, GAN J. Determination of enantiomers of synthetic pyrethroids in water by solid phase micro- extraction-enantioselective gas chromatography [ J ]. Journal of Agriculture and Food Chemistry, 2004,52: 736-741.
  • 10商永严,孙楠,胡宝祥,莫卫民.吡氟禾草灵的高效液相色谱法拆分与测定[J].理化检验(化学分册),2008,44(4):319-320. 被引量:2

二级参考文献33

共引文献8

同被引文献4

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部