摘要
目的探讨尼莫地平联合氟西汀治疗脑卒中后抑郁的疗效，并分析其安全性。方法脑卒中后抑郁患者72例，采用随机数字表格法分为观察组与对照组，各36例，其中对照组给予氟西汀治疗，观察组给予尼莫地平联合氟西汀治疗。比较两组患者的临床效果，并评价药物安全性。结果观察组治疗有效率83．33％，显著高于对照组的52．78％（X2=6．15，P〈0．05）。观察组治疗后HAMD评分（5．6±1．7）分，MMSE评分（23．6±3．3）分，CSS评分（11．5±5．7）分，MBI评分（66．1±11．7）分，与治疗前比较差异有统计学意义（t=5．12、4．72、3．28、7．10，均P〈0．05），且与对照组治疗后比较差异有统计学意义（t=2．31、2．62、4．38、5．10，均P〈0．05）。结论尼莫地平联合氟西汀可显著提高脑卒中后抑郁患者的临床疗效，且能够明显改善患者的认知功能及神经功能，值得临床推广。
Objective To investigate the clinical effect of nimodipine combined with fluoxetine in treatment of post-stroke depression and analyze its security. Methods 72 patients with post-stroke depression were divided into observation group and control group by random number table method, 36 cases in each group. The control group was given fluoxetine,while the observation group was given nimodipine combined with fluoxetine treatment. The clinical effects and the drug safety were compared between the two groups. Results The effective rate of the observation group was 83.33% ,which was significantly higher than 52.78% in control group（ X2 =6.15 ,P 〈0.05 ）. After treat- ment,in the observation group,HAMD score （5.6 ~ 1.7） ,MMSE score （23.6 ＋3.3） ,CSS score （ 11.5：1：5.7） ,MBI score （66.1 ＋ 11.7）, had statistically significant differences compared with before treatment （ t = 5.12,4.72,3.28, 7. 10, all P 〈 0.05 ）, and compared with those of the control group after treatment, the differences were statistically sig- nificant（t = 2.31,2.62,4.38,5.10, all P 〈 O. 05 ）. Conclusion Fluoxetine combined with nimodipine can signifi- cantly improve the clinical efficacy of post-stroke depression ,and it can significantly improve patients＇ cognitive func- tion and nerve function, which is worth to be promoted in clinical.
出处
《中国基层医药》
CAS
2013年第24期3748-3750,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑血管意外
抑郁症
尼莫地平
氟西汀
Cerebrovascular accident
Depressive disorder
Nimodipine
Fluoxetine
