摘要
本试验采用随机对照方法 ,评价了万乃洛韦治疗复发性生殖器疱疹的有效性、安全性及适宜疗程。共治疗 10 1例患者 ,其中万乃洛韦一周组 36例 (30 0 mg,每天 2次 ) ,万乃洛韦一月组 35例 (30 0 mg,每天 2次 ) ,阿昔洛韦一月组 30例 (2 0 0 mg,每天 5次 )。结果显示 ,万乃洛韦一周和一月组起效时间均比阿昔洛韦组明显加快 (P<0 .0 1) ,并能缩短疗程 ,但三组之间无显著性差异 (P>0 .0 5 )。万乃洛韦一月组能显著降低患者复发频率 (P<0 .0 1) ,另两组则否。结果表明 ,万乃洛韦一月疗法治疗复发性生殖器疱疹安全有效 ,能显著降低复发频率 ,患者依从性好 ,是治疗该病较好的药物和较适宜疗程。
A randomized controlled clinical trial was conducted to evaluate the efficacy, safety and suitable course of treatment of valaciclovir in the treatment of recurrent genital herpes. A total of 101 patients included in the study, 36 cases in valaciclovir group of one week therapy (300mg,bid); 35 cases in valaciclovir group of one month therapy (300mg, bid); 30 cases in acyclovir group of one mouth therapy (200mg, 5qd), respectively. Results showed that two valaciclovir groups were significantly faster than the acyclovir group in taking effect time ( P <0.01), and could shorten the course of treatment, but there were no significant difference in three groups ( P >0.05). The valaciclovir group of one month therapy could significantly reduce recurrence frequency ( P <0.01), but not the other two groups. It was concluded that valaciclovir of one month therapy is effective, safe and good compliance, and also reduce significantly recurrence frequency in the treatment of recurrent genital herpes, is a better drug and suitable course of treatment.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第6期475-477,共3页
Chinese Journal of Antibiotics
关键词
万乃洛韦
疗程
生殖器疱疹
药物治疗
Valaciclovir
Acyclovir
Course of treatment
Genital herpes
