摘要
目的观察健脾祛湿清热凉血方内服配合消瘀止痛药膏外用治疗急性痛风性关节炎的临床疗效。方法将急性痛风性关节炎患者96例随机分为治疗组与对照组各48例,治疗组给予健脾祛湿清热凉血方内服,每日1剂,同时予消瘀止痛药膏外敷,每24h更换1次。对照组给予秋水仙碱片口服,初始剂量为1mg,随后0.5mg/h或1mg/2h,直到症状缓解,最大剂量6～8mg/d;症状缓解后0.5mg,每天2～3次。两组疗程均为7天,比较两组患者治疗前后血沉(ESR)、C反应蛋白(CRP)、白细胞(WBC)、血尿酸(UA)、症状及体征积分,并观察临床疗效与不良反应。结果两组患者治疗后ESR、CRP、WBC、UA、症状及体征积分较治疗前均明显降低(P<0.05);两组治疗后肿胀积分比较差异有统计学意义(P<0.05);治疗组临床疗效总有效率为89.6%,对照组为87.5%,两组比较差异无统计学意义(P>0.05)。结论健脾祛湿清热凉血方内服配合消瘀止痛药膏外敷治疗急性痛风性关节炎疗效确切,能明显改善临床症状和体征,降低UA。
Objective To observe the therapeutic effect of Spleen-Fortifying Dampness-Dispelling Heat-Clearing BloodCooling Formula（SDHBF）combined with Stasis-Dispersing Pain-Relieving Topical Ointments（SPTO）for acute gouty arthritis.Methods Totally 96 cases of acute gouty arthritis were randomized into the treatment group and control group,with 48 in each.The treatment group was given one dose of SDHBF daily and SPTO once per 24 hours.The control group was orally given colchicine tablets from the initial dose of 1mg,then 0.5mg/h or 1mg/2h to maximum dose of 6-8mg/d until the symptoms relieved and 0.5mg 2 or 3 times daily after remission.The treatment lasted for 7 days.The erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）,white blood cell（WBC）,uric acid（UA）,symptoms score and signs score were compared between groups and within group before and after treatment.The therapeutic effect and adverse reactions were observed.Results The ESR,CRP,WBC,UA,symptoms score and signs score were significantly decreased in both groups after treatment（P〈0.05）.There was a significant difference between groups in the swelling score after treatment（P〈0.05）.The total effective rate of the treatment group and control group was 89.6% and 87.5% respectively,with no significant difference between groups（P〈0.05）.Conclusion The combo therapy of SDHBF and SPTO is effective for acute gouty arthritis and it can obviously relieve the clinical symptoms and signs and reduce UA.
出处
《中医杂志》
CSCD
北大核心
2013年第24期2121-2123,共3页
Journal of Traditional Chinese Medicine
关键词
健脾祛湿清热凉血方
急性痛风性关节炎
消瘀止痛药膏
尿酸
Spleen-Fortifying Dampness-Dispelling Heat-Clearing Blood-Cooling Formula
acute gouty arthritis
StasisDispersing Pain-Relieving Topical Ointments
uric acid
