摘要
目的 检测卵巢上皮癌中内皮抑素（ES）及碱性成纤维生长因子（bFGF）的表达并分析两者的表达相关性以及与临床病理特征之间的关系.方法 应用免疫组织化学SP法检测80例卵巢癌组织中ES和bFGF的表达情况.结果 bFGF在卵巢上皮癌中的表达与临床分期、病理分化程度及盆腔转移密切有关（均P＜0.05）.ES的表达在中分化患者高于高分化,在Ⅰ～Ⅲ期逐渐升高,但在低分化及Ⅳ期反而降低;在有盆腔结转移的卵巢癌组织的表达率高于无盆腔转移（均P＜ 0.05）.ES与bFGF在卵巢上皮癌中表达无相关性（P.＞0.05）.结论 ES在恶性程度高的组织中表达较强,但到一定程度表达会失代偿.bFGF高表达者恶性程度高,浸润性强.通过与bFGF竞争受体是ES抗血管生成作用的重要途径之一,但不占主导地位.
Objective To detect the expression of Endostatin（ES） and basic fibroblast growth factor （bFGF） in epithelial ovarian cancer and fred the relationships between them, as well as the relationships between expressions and clinical and pathological parameters, so as to determine the roles of bFGF and ES in the growth and invasion of ovarian cancer. Methods Immunohistochemistry was used to dectect 80 specimens of paraffin sections of post-operation ovarian cancer. Results The expression ofbFGF was associated with pathological grades and clinical stage of ovarian cancers（P 〈 0.05）, and was higher in the lymph node metastasis group. The expression of ES in the moderately differentiated group was higher than that in well-differentiated group, and raised gradually from grade Ⅰ to grade Ⅲ; but the expression orEs in the poorly differentiated group and grade Ⅳ was lower; the expression was associated with lymph node metastasis （P 〈 0.05）. There was no correlation found between ES and bFGF expressions. Conclusions The expression of ES will increase when clinical stage increased in some range, but not all the time. The enhanced expression ofbFGF shows higher malignant extent and more powerful invasion. The effect on bFGF pathway is one of the most important mechanisms of ES, but maybe not the dominant one.
出处
《现代实用医学》
2013年第11期1212-1214,1256,F0003,共5页
Modern Practical Medicine
关键词
卵巢肿瘤
卵巢上皮癌
内皮抑素
碱性成纤维生长因子
Ovarian neoplasm
Epithelial Ovarian Cancer
Endostatin
Basic fibroblast growth factor
