摘要
目的观察服用丙戊酸(VPA)的癫痫患者肝功能的变化,并对其影响因素进行分析,以求规范VPA的临床应用及减少毒副作用。方法对2010年11月～2012年4月在中国医科大学附属第一医院诊断为癫痫同时进行血药浓度检测的119例单独服用VPA的患者,采取Logistic回归分析考察性别、血药浓度、年龄是否为肝酶异常的影响因素。结果服用VPA可以明显升高肝酶,肝酶指标的变化与患者性别和VPA血药浓度无关,只与年龄相关,20岁以下年龄越大肝酶异常概率越低。结论对使用VPA的患者实行个体化治疗,尤其是儿童,应充分考虑患儿的各项生理指标,适时进行血药浓度监测,及时调整给药剂量,采取相应药学监护措施,使儿童应用VPA更安全、合理、有效。
Objective To observe the hepatic enzymes changes and analyze the involved factors in the epilepsy patients after taking Valproic Acid （VPA）,so as todevelop the treatment protocol or reduce the side effects.Methods 119 serum concentration samples of VPA were tested,who were diagnosed as epilepsy by the doctors in the First Affiliated Hospital of China Medical University from November 2010 to April 2012,the relationships between liver enzyme changes and age,gender,serum concentration were analyzed by Logistic regression analysis.Results VPA enhanced hepatic enzyme indicators significantly.These indicators were associated to the patients＇ age only,which were not associated to the gender or serum concentration of VPA.The older age the patients were,the less injury the livers had of patients under 20 years old.Conclusion It is necessary to make out individual therapeutic regimen,especially for the children,all kinds of physiological indicators should be considered,watch the serum concentration of VPA in time,and take corresponding measures,so that the patients＇ safety can be guaranteed.
出处
《中国医药导报》
CAS
2013年第25期73-75,共3页
China Medical Herald
基金
辽宁省沈阳市科学技术计划项目(编号F12-277-1-79)
关键词
癫痫
丙戊酸
肝损伤
Lepsy
Valproic Acid
Hepatic injury
