摘要
近年来肥胖所引起的不可逆性心血管疾病的发病呈明显增加趋势,其发病的根源为血管内皮的损伤.该文通过对肥胖引起的内皮素-1、NO、纤溶酶原激活物抑制物-1、血管内皮生长因子及内皮祖细胞等的改变,从而引发高血压、冠心病等心血管疾病的原因及机制进行了系统的阐述,认为肥胖可引起血管收缩舒张失衡、抗凝与促凝失衡、生长因子与生长抑制因子失衡及内皮祖细胞数量、形态的变化.
The onset of irreversibility of cardiovascular diseases caused by obesity has showed a rising trend,the underlying cause of the disease is the endothelial damage.Injury caused by obesity through four aspects：systolic and diastolic imbalance,anticoagulant and procoagulant imbalance,growth factors and growth factor imbalances and endothelial progenitor cell changes in endothelial damage.This paper reviews the reason and the mechanism of the endothelial damage through the change of the endothelial factors and progenitor cells.
出处
《国际儿科学杂志》
2013年第6期579-582,共4页
International Journal of Pediatrics
关键词
肥胖
内皮因子
内皮祖细胞
Obesity
Endothelial factor
Progenitor cell
