摘要
目的基于粒子设计原理,制备并表征具有核壳结构的青黛-白矾复合粒子。方法以粒径为评价指标,研究壳粒子的制备时间;以接触角为评价指标,研究复合粒子的复合时间。分别制备青黛细粉、白矾细粉、青黛-白矾细粉混合物及青黛-白矾复合粒子,从粒径分布、粉末颜色、微观结构、表面元素分布及晶型结构方面对比研究4种粉末的差异,以表征复合粒子的核壳结构。结果壳粒子在振动磨中粉碎17 min后加入核粒子,两者一起复合5 min,复合粒子的表面润湿性与壳粒子无显著差异。4种粉末在粒径分布、颜色、微观结构、表面元素分布及晶型结构上存在显著差异;复合粒子的众位粒径d0.9为32.818μm,远小于混合物,其颜色、表面元素分布与壳粒子高度类似,扫描电镜(SEM)观察到存在众多小颗粒包覆在大颗粒表面的微观结构,X射线衍射谱中核粒子大部分的特征峰消失或强度减弱。结论成功制备出了具有核壳结构的青黛-白矾复合粒子,其表面性质与壳粒子类似,与核粒子明显不同。
Objective To prepare and characterize Indigo Naturalis-Alumen （INA） composite particles with core-shell structure based on the particle design principle. Methods The preparation time of shell particles and composition time of composite particles were studied using particle size and contact angle as evaluation indexes, respectively. Four kinds of powders including Indigo Naturalis fine powder, Alumen fine powder, INA mixture, and INA composite particles were prepared respectively; Their properties such as particle size, powder color, microstructure, distribution of surface elements, and crystal structure were compared, so as to study the core-shell structure of composite particles. Results During the period of the preparation, the shell particles were added into vibromill and ground for 17 min separately, and then the core particles were added and ground with shell particles together for 5 min. There was no difference between the composite particles and shell particles in surface wettability. The median diameter （d0.9） of the composite particles was 32.818 μm, which was much smaller than that of the mixture. The color and surface elements distribution were highly similar to the shell particles. In SEM, the microstructure that the surface of big particles coated with a large number of small particles could be observed. In X-ray diffractogram, many characteristic absorption bands of the core particles were disappeared or decreased. Conclusion INA composite particles with core-shell structure are prepared successfully, the surface properties are similar to the shell particles and are different with the core particles.
出处
《中草药》
CAS
CSCD
北大核心
2013年第24期3457-3464,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(30973952,81274098)
关键词
粒子设计
复合粒子
核壳结构
制备
青黛
白矾
particle design
composite particles
core-shell structure
preparation
lndigo Naturalis
Alumen
