摘要
目的探讨幽门螺杆菌（H．pylori）感染与冠心病（CHD）患病相关因素的关系，了解幽门螺杆菌（H．pylori）感染在冠心病发病中的作用及清除H．pylori在预防和治疗冠心病（CHD）中的必要性。方法选取2012年10月～2013年2月住院，经检查确诊为冠心病患者91例为研究对象；另选取同期在医院进行健康查体的98例健康人作为健康对照组，采用化学发光法进行血清同型半胱氨酸（Hcy）水平检测；血糖（GLU）采用酶法进行检测，应用透射比浊法对纤维蛋白原（FIB）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、三酰甘油（TG）、胆固醇（TC）进行检测；采用脲酶试验进行幽门螺杆菌（Hp-IgG）抗体的检测，并对所有检测结果进行统计分析。结果①冠心病患者H．pylori感染率（45．05％）明显高于健康对照组（28．57％）（t=5．531，P〈O．05）；②冠心病患者FIB，LDL，TC和Hcy水平（2．98±0．70g／L，2．72±1．00mmol／L，4．88±0．86mmol／L和24．56±16．08μmol／L）明显高于健康对照组（2．61士0．52g／L，2．39±0．85retool／L，3．77±1．52mmol／L和17．93±13．99μmol／L）（t=0．33～7．56，P值均〈0．01）。冠心病患者HDL的水平（0．94±0．22mmol／L）明显低于健康对照组（1．27±0．30mmol／L）（t=5．86，P〈0．01）。冠心病患者GLU和TG的水平（5．4±1．54mmol／L和1．70±0．74mmol／L）与健康对照组（5．4±0．89mmol／L和1．75土0．85mmol／L）比较差异无统计学意义（t=2．18，10．08，P值均〉O．05）；冠心病患者Hp-IgG（＋）与Hp-IgG（-）比较，FIB，LDL，TC和Hey升高差异有统计学意义（t=3．65～6．66，P值均〈0．01），HDL下降非常显著，差异有统计学意义（t=4．45，P〈0．01），而GLU和TG水平Hp-IgG（＋）与Hp-IgG（-）组比较则差异无统计学意义（t=0．30，7．23，P值均〉0．05）。结论H．pylori感染是冠心病危险因素，H．pylori感染可能通过对血清Hey及血脂代谢的影响而促进冠心病的发生和发展，清除H．pylori是预防冠心病行之有效的方法。
Objective To discusses the correlation between the helicobacter pylori （H. pylori） infection and coronary heart disease（CHD） ,and to know more about the function of H. pylori infection in the development of coronary heart disease and the necessity of clearing H. pylori in the prevement and treatment of CHD. Methods 91 CHD patients diagnosised in Xijing Hospital from Oct 2012 to Feb 2013 and 98 healthy subjects were enrolled in this study. The serum levels of homocyst were measured by chemiluminescence immunoassay （CLIA）, GLU was measured by enzymic method, FIB, LDL, HDL, TG and TC were measured by turbidimetry and the serm antibodies to H. pylori were measured by urease test. Allconsecunses were analyzed by statistics. Results （1）The infection rate of HP in CHD group （45.05%） was obviously higher than the control group （28.57 % ） （x2 = 5.531, P〈0.05） ; （2） Comparing to the control group, the serm levels of FIB, LDL, TC and Hey （2.98 ±0.70 g/L, 2.72 ± 1.00 mmol/L,4.88±0. 86 mmol/L and 24.56±16.08 μmol/L） were significantly higher than the CHD group （t=0. 33±7.56,P〈0.01） ,while the serm level of HDL was obviously lower （1.27±0.30 mmol/L） （t=5.86 P〈 0.01）. But the serm levels of GLU and TG had no differences between CHD and the control groups （t=2.18,10.08,P〉 0. 05）. In the cHD group,the serm levels of FIB,LDL,TC （t=3.65±6.66,P〈0. 01） and Hey increased while the serm level HDL decreased for Hp-IgG （q-） patients （t=4.45, P=0.01）,but the serm levels of GUL and TG had no obviosely differences between Hp-IgG （-[-） and Hp-IgG （--） patients （t=0.30,7.23,P〈0. 05）. Conclusion The infection of HP is one of risk factors for CHD. The infection of HP would advance the development of CHD through effecting the metabolism of Hcy and blood fat. To clear HP is a validate method for preventing the happenchance of CHD.
出处
《现代检验医学杂志》
CAS
2013年第6期18-21,共4页
Journal of Modern Laboratory Medicine
关键词
幽门螺杆菌
冠心病
同型半胱氨酸
血脂
感染
helicobacter pylori
coronary heart diseaseb
homocyst
blood lipids
infection
