摘要
新生儿乙肝血源疫苗全程接种后 5～ 9年抗 -HBs阳性率和滴度 (MIU/ml)明显下降 ,约75%抗 -HBs水平在保护性水平 ( <10MIU/ml)以下。但乙肝表面抗原HBsAg阳性率与免疫后一年比较无明显差异 ,仍有很好保护效果。应用 5μg乙肝基因疫苗加强免疫一剂 ,再免后一个月抗 -HBs阳性率和滴度 (MIU/ml)明显升高 ,分别提高 2 8 60 %和 2 90倍 ,对抗 -HBs
Both the positive seroconversion rate and titer of anti HBs(mIU/ml) in the newborns who have been vaccinated with plasma derived hepatitis B vaccine in 1988～1992 have decreased markedly.About 75 percent of the newborns' antibody titer of anti-HBs was less than the protective titer level (<10 mIU/ml).But there was no significant difference in the positive seroconversion rate of HBsAg between pre-vaccination and one year after vaccination. It still has a good protective effect.After one month of vaccination with one dose (5μg) recombined yeast hepatitis B vaccine boost,the positive seroconversion rate and titer of anti-HBs have risen by 28.60% and 20.9% respectively.There was good recall reaction with boost vaccination in the children whose anti-HBs titer were less than 10 mIU/ml.
出处
《疾病监测》
CAS
2000年第7期245-247,共3页
Disease Surveillance
