摘要
目的:研究葛根总黄酮分散片在大鼠体内的药代动力学特征及生物利用度,并与市售愈风宁心片进行比较。方法:大鼠灌胃给药葛根总黄酮分散片(受试制剂)及市售片(参比制剂)混悬液,采用HPLC测定给药后各时间点的血药浓度,用统计软件计算主要药代动力学参数。结果:分散片与市售片的C max分别为(20.21±0.18),(9.90±0.25)mg·L-1;分散片的T max=(0.50±0.03)h,市售片T max=(1.09±0.02)h;分散片相对于市售片的生物利用度为182.68%。结论:葛根总黄酮分散片吸收快,起效时间明显提前,生物利用度明显优于市售片。
Objective： To study and compare the serum concentration and pharmacokinetics of disperible tablets of Pueraria lobata flavone and Yufeng Ningxin tablet in rats. Method： The mice were given disperible tablets of Pueraria lobata flavone and Yufeng Ningxin tablet, HPLC was used to test the serum concentration at different time points and design conditions of pharmacokinetics by statistical software. Result： The Cmax of disperible tablets of Pueraria lobata flavone and merchant tablet was （20.21 ± 0. 18）, （9.90 ± 0.25 ） mg.L^-1 The dispersible tablet T was （0.50 ± 0.03） h, merchant tablet being （ 1.09 ± 0.02） h. Conclusion： Disperible tablets of Pueraria lobata flavone has rapid absorbtion, the onset time was rapaid and the pharmacokinetics was superior to the control group.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第1期107-110,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省高等学校大学生创新实验项目(1057310021)
关键词
葛根总黄酮
分散片
愈风宁心片
血药浓度
药代动力学
Pueraria lobata flavone
dispersible tablet
Yufeng Ningxin tablet
serum concentration
pharmacokinetics
