摘要
目的：对原发腹膜后平滑肌肉瘤（retroperitoneal leiomyosarcoma，RLMS）病人的临床和病理特征进行分析，探讨与预后相关的因素。方法：回顾性分析2009年5月至2012年5月我院收治的2l例RLMS病人．分析临床和病理特征对疾病无进展（freedom from progression，FFP）时间的影响。采用免疫组化标记CD34，对18例病人肿瘤计数微血管密度（microvessel density，MVD）。结果：中位随访24（4～39）个月，13例病人出现复发或疾病进展．中位FFP时间20个月，18例病人的中位MVD为每10个高倍视野94个。单因素分析发现，就诊时转移（P〈O．0001）、FNCLCC评分分级（P〈O．0001）、是否手术完整切除（P〈0．0001）、MVD（P=O．009）与FFP时间相关；多因素分析仅显示FNCLCC评分和手术完整切除是FFP时间的独立预后因子（P〈0．05）。结论：FNCLCC评分、RLMS是否完整切除与病人的预后相关；低MVD的病人可能有较好的预后。
Objective To analyze the prognostic factors associated with primary retroperitoneal leiomyosarcoma （RLMS）. Methods Clinical and pathological data of 21 patients with RLMS from May 2009 to May 2012 in our hospital were reviewed. Microvessel density （MVD） was counted in 18 patients by immunohistochemistry with vascular marker CD34. Univariate and multivariate analysis were performed for freedom from progression （FFP） time. Results The median follow-up was 24 （4-39） months. Median FFP time was 20 months. Thirteen patients recurred RLMS or progressed. Median MVD was 94 per 10 high power fields in the 18 patients. Univariate analysis showed that no metastasis before treatment, low FNCLCC score, complete resection and low MVD level were the factors associated with a favorable FFP time. However, FNCLCC score and complete resection were the independent prognostic factors according to COX proportional hazards models. Conclusions Both FNCLCC score and complete resection are associated with the favor prognosis of RLMS. Lower MVD is with better prognosis.
出处
《外科理论与实践》
2013年第6期546-551,共6页
Journal of Surgery Concepts & Practice
