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乙型肝炎病毒S区基因变异研究进展 被引量：5

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摘要 乙型肝炎病毒（HBV）为一嗜肝细胞DNA病毒,不仅可以引起隐匿性、急性和慢性病毒性肝炎,还与肝硬化和肝细胞癌的发生发展密切相关。虽然通过对HBV和宿主及其相互作用的研究,已经发展了有效的预防疫苗和多种抗病毒药物,但HBV感染仍是世界范围内的公共健康问题[1-2]。本文针对HBV S基因的结构和功能上,以及目前关注较多的免疫逃逸、隐匿性肝炎和耐药突变引起方面S基因变异的研究进展作一综述。
作者 荣义辉 辛绍杰
机构地区 解放军第三○二医院肝衰竭诊疗与研究中心
出处 《肝脏》 2013年第11期779-781,共3页 Chinese Hepatology
基金 国家"十二五"科技重大专项课题"乙型肝炎病毒感染所致肝衰竭临床救治方案的研究"(2012ZX10002004-005)
关键词 乙型肝炎病毒 S区基因变异 HBV感染 慢性病毒性肝炎 S基因变异 肝细胞癌 DNA病毒 抗病毒药物
分类号 R373 [医药卫生—病原生物学]
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共引文献35

同被引文献43

  • 1许倩,于晓辉,吴雄志,赵连三.乙型肝炎病毒免疫逃逸机制研究[J].中国综合临床,2004,20(9):861-863. 被引量：1
  • 2唐国建,杨义伟,蒋海燕,王前进,王永忠.乙型肝炎病毒基因分型及临床应用[J].放射免疫学杂志,2006,19(4):337-339. 被引量：2
  • 3Alexander AM, Yamitzel Z, Chen CH, et al. Molecular characteri- sation of hepatitis B virus in the resident Chinese population in Pan- area City [J]. Mere Inst Oswaldo Cruz, 2013, 108(5): 541 - 547.
  • 4Tong WB, Sun L, He JL, et al. A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier[J]. Virology Journal, 2010, 7: 104.
  • 5Hsu HY, Chang MH, Ni YH, et aL Long - term follow - up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant. See comment in PubMed Commons below[J]. J Infect Dis, 2013, 207(7) : 1047 - 1057.
  • 6Rodriguez - Frias F, Buti M, Jardi R, et al. Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B, chronic hepatitis B andhepatitis B liver cirrhosis before and after liv- er transplantation[J]. Liver, 1999, 19(3): 177-182.
  • 7Thuy T, Thi L, Ryo H, et al. Distribution of genotype/subtype and mutational spectra of the surface gene of hepatitis B viruseirculating in Hanoi, Vietnam[J]. J Med Virol, 2005, 76(2) : 161 -169.
  • 8Srey CT, Ijaz S, Tedder RS, et al. Characterization of hepatitis B surface antigen strainscirculating in the Kingdom of Cambodia [ J ]. J Viral Hepat, 2006, 13(1) : 62 -66.
  • 9何卫平,陈婧,胡瑾华.非活动性HBsAg携带者临床病理分析[J].临床肝胆病杂志,2008,24(1):22-23. 被引量：5
  • 10LU Feng-min ZHUANG Hui.Management of hepatitis B in China[J].Chinese Medical Journal,2009(1):3-4. 被引量：661

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肝脏
2013年 第11期

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