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不同部位脑出血患者肠黏膜屏障功能变化研究 被引量:3

Study on intestinal mucosal barrier in patients with different cerebral hemorrhage
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摘要 目的探讨不同部位脑出血(基底节区出血、脑干出血)患者肠黏膜屏障变化。方法选取脑出血患者共66例,其中脑干出血32例,基底节区出血34例,分别于患病后24h、72h、2w、4w采集静脉血,同时选取健康体检者30例作为对照,抽取外周血,采用双抗体夹心ELISA法测定血清二胺氧化酶(DAO)、D-乳酸(D-LAC)含量。结果无论基底节区出血还是脑干出血,患者在患病后很快出现肠黏膜屏障功能的改变,在患病24h达较高水平,随后的72h、1w及2w血清D-LAC及DAO持续高水平,两组患者于2w后呈降低趋势,两组在发病后4w明显降低,但仍高于对照组;结论不论基底节区出血还是脑干出血患者患病后24h内即可出现黏膜屏障功能损伤,两组患者肠黏膜屏障功能损伤可持续4w或更长时间。 Objective To study the changes tff intestinal mucosal battier in patier, ts with different cerebral hemorrhage (hemisphere hemorrhage brain stem hemorrhag). Methods 66 patients with cerebral hemmThage (34 was hemisphere hemorrhage and 32 was brain stem hemorrhag) , respectively in 24h, 72h,2w ,4w after the illness, venous blood was collected, and 30 healthy subjects served as control , The serum diamine oxidase (DAO) and D-lactic acid (D-LAC) were detected in 66 patients and 30 normal controls by double antibody enzyme linked immunosorbent assay .Results Whether hemispheric hemorrhage or brain stem hemorrhage, patients with intestinal mucosal barrier flmction changes soon after illness sickness, in 24 h 72 h, 1 week anti 2 weeks serum D-LAC and DAO levels remained high, lasted a higher level. The two groups patients showed decreasing trend after 2 w, and significantly decreased after 4 w, but still higher than that of the control group.Conclusion Hemisphere hemorrhage and brain stem hemorrhage patients can appear mucous membrane barrier function damage after illness in 24 h, and the damage can last 4 w or longer.
出处 《脑与神经疾病杂志》 2013年第6期432-434,共3页 Journal of Brain and Nervous Diseases
关键词 脑出血 肠黏膜通透性 肠黏膜屏障 Cerebral hemorrhage Intestinal permeability Intestinal mucosal barrier
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  • 1Dervenis C, Smailis D, Hatzitheoklitos E.Baeteria] |ranslocation and its prevention in acute pancreatitis.J Hepatobiliary Pancreat Surg, 2003, 10.415-418,.
  • 2de Oliveira EP, Burini RC. The impact of physical exercise on the gastr'ointestinal tract. CuT ()pi Clin Nutr Metab Care, 2009, 12: 533-538.
  • 3Peters HP, De Vries WR, Vanherge-Henegouwen GP, et al. Potential benefits and hazards of physical aetivity and exercise on the gastrointestinal tract. Gut, 2001,48 : 435-439.
  • 4Guamer C,Soriano G. Baeterial trans[ocation al(] its consequen(es i,l patients with cirrhosis.Eur J Gastroenterol Hepatol, 2005,17 : 27-31.
  • 5Murray R. Training the gut for competition. Curt Sporis . Mcd Rep, 2006,5 : 161-164.
  • 6邱月,宁显忠.脑出血大鼠肠黏膜组织形态学变化与血浆儿茶酚胺水平的关系[J].中风与神经疾病杂志,2012,29(2):129-132. 被引量:6
  • 7Thuijls G, de Haan J J, Derikx JP, et al. Intestinal eytoskclet on degradation precedes tight junction loss tollowing hemmThagic shock . Shock, 2009; 31:164-169.
  • 8Fennerty MB.Pathophysiolngy of the upper gastrointestinal tract in tlle critically ill patient: Rationale tbr the therapeutic benefits of acid suppression.Crit Care Med,2002,30(6suppl)351-355.
  • 9王建林,张苏明,杨志秀,张晓敏,范云虎,王静梅.脑出血大鼠血清白蛋白水平与肠黏膜变化的关系[J].中华神经科杂志,2010,43(11):801-804. 被引量:7

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  • 1蒋力生,陈鹏.脓毒症与内毒素血症的治疗现状与展望[J].中国普外基础与临床杂志,2004,11(6):551-553. 被引量:14
  • 2de Oliveira EP, Burini RC. The impact of physical exercise on the gastrointestinal tract [ J]. Curr Opin Clin Nutr Metab Care, 2009, 12 (5): 533-538.
  • 3Peters HP, De Vries WR, Vanberge - Henegouwen GP, et al. Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract [J]. Gut, 2001, 48 (3): 435-439.
  • 4Mesejo A, Juan M, Gareia - Simon MD. Enter access and intestinal function assessment in the critically ill patient [ J ]. Nutr Hosp, 2007, 22 (suppl2): 37-49.
  • 5Fouts DE, Torralba M, Nelson KE, ctal. Bacterial translocation and changes in the intestinal mierobiome in mouse models ofliver disease [J]. J Hepatol, 2012, 56 (6): 1283-1292.
  • 6Pathan N, Burmester M, Adamovie T, et al. Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease [J]. AmJRespirCritCareMed, 2011, 184 (11): 1261-1269.
  • 7Karima R. The molecular pathogenesis of endotoxic shock and organ failure [J]. Mol MedToday, 1999, 5 (3): 123-132.
  • 8王惠凌,李同凯,王德超,等.美洛两林钠与头孢哌耐舒巴坦治疗早发性卒中相关性肺炎临床观察[J].脑与神经疾病杂志,2013,21(6):264-267.
  • 9龙凯,李雄文.早期肠内营养支持对重症脑卒中患者营养状况及并发症的影响[J].实用心脑肺血管病杂志,2014,22(9):119-120.
  • 10de Oliveira EP, Burini RC. The impact of physical exercise on the gastrointestinal tract [ J ]. Curt Opin Clin Nutr Metab Care, 2009, 12 (5): 533-538.

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