期刊文献+

蛋白质组学在药物研究中的应用

下载PDF
导出
摘要 随着后基因时代的到来,蛋白质组学得到了迅猛的发展,与蛋白质相关的药物研究在这一领域也取得了巨大的进展。本文主要介绍了蛋白质组学的主要技术,和蛋白质组学在药物研发中的应用进展。
出处 《中国医药指南》 2013年第36期366-368,共3页 Guide of China Medicine
  • 相关文献

参考文献24

  • 1Anderson NL,Anderson NG.Proteome and proteomics:new techn- ologies,new concepts and new words[J].Electrophoresis,1998,19 (11):1853-1861.
  • 2Collins FC,Green ED.Guttmacher AE et al A version for the future of genomics research[J].Nature,2003,422(6934):835-847.
  • 3Tyer M,Mann M.Form genomics to proteomics[J].Nature,2003, 422(6928) :193-197.
  • 4Caron PR,Mullican MD,Mashal RD,et al.Chemogenomic appro- aches to drug discovery[J].Curr Opin Chem Biol,2001,5(4):464- 470.
  • 5蒋宁,周文霞,张永祥.药物蛋白质组学研究进展[J].中国新药杂志,2005,14(12):1391-1394. 被引量:4
  • 6Klein E,Klein JB,Thongboonkerd V.Two dimension algelelectr- ophoresis :a fundamental tool for expression proteomics studies [J].Proteomics in Nephrology,2004,141:25-39.
  • 7Angelika Gorg,Walter W, Michael JD.Current two-dimensional electrophoresis technology for proteomics[J].Proteomics,2004,4 (12):3665-3685.
  • 8Steiner S,Gatlin CL,Lennon JJ,et al.Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatins[J].Toxicol lett,2001,120(5):369-377.
  • 9Steiner S,Gatlin CL,Lennon JJ,et al.Proteomics to display lovastatin- induced protein and pathway regulation in rat liver[J].Electrophor esis,2000,21 (14):2129 -2137.
  • 10李勤,黄建安,刘硕谦,李娟,刘仲华.茶树蛋白质双向电泳样品制备技术研究[J].茶叶科学,2011,31(3):173-178. 被引量:14

二级参考文献40

  • 1于雁灵,芮耀诚,杨鹏远,樊惠芝,黄珍玉,杨原.辛伐他汀对家兔动脉粥样硬化血管组织作用的蛋白质组研究[J].药学学报,2003,38(7):511-514. 被引量:16
  • 2G rg A, Obermaier C, Boguth G, et al. Very alkaline immobilized pH gradients for two-dimensional electrophoresis of ribosomal and nuclear proteins[J]. Electrophoresis, 1997, 18(3/4): 328-337.
  • 3Abbott A. A post-genomic challenge: learning to read patterns of protein synthesis[J]. Nature, 1999, 402(6763): 715-720.
  • 4Gygi S, Rochon Y, Franza B, et aL Correlation between protein and mRNA abundance in yeast[J]. Molecular and Cellular Biology, 1999, 19(3): 1720.
  • 5Li J, Assmann S. Mass spectrometry. An essential tool in proteome analysis[J]. Plant Physiology, 2000, 123(3): 807.
  • 6Wasinger V, Cordwell S, Cerpa-Poljak A, et al. Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium[J]. Electrophoresis, 1995, 16(1): 1090-1094.
  • 7Gorg A, Weiss W, Dunn M. Current two-dimensional electrophoresis technology for proteomics[J]. Proteomics, 2004, 4(12): 3665-3685.
  • 8Rabilloud T. Solubilization of proteins for electrophoretic analyses[J]. Electrophoresis, 1996, 17(5): 813-829.
  • 9Damerval C, De Vienne D, Zivy M, et al. Technical improvements in two-dimensional electrophoresis increase the level of genetic variation detected in wheat-seedling proteins[J]. Electrophoresis, 1986, 7(1): 52-54.
  • 10Wang W, Vignani R, Scali M, et al. A universal and rapid protocol for protein extraction from recalcitrant plant tissues for proteomic analysis[J]. Electrophoresis, 2006, 27(13): 2782-2786.

共引文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部