摘要
目的探讨血脂异常,包括高胆固醇（TC）、高甘油三脂（TG）对血小板分布宽度（PDW）的影响。方法以苏州市相城区3 958名中老年常住居民为研究对象,收集身高、体重、血压和疾病史,检测血TC、TG、血糖、尿酸（UC）以及血小板计数（PLT）、平均血小板体积（MPV）、PDW,采用Logistic回归分析PDW与血脂相关指标的关联性大小。结果血脂异常人群中PDW水平及PDW升高的比例均高于对照组（P〈0.05）,血脂异常组中PLT水平也高于对照组（P=0.009）,而MPV在两组的差别未发现有统计学意义;并且PDW升高者中高甘油三酯比例、血脂异常的比例也均高于PDW正常组。Logistic回归结果显示,调整多个因素后,血脂异常、甘油三脂升高者均会增加PDW升高的危险,其OR值分别为1.91（1.19~3.06）和3.22（1.96~5.29）。结论血脂异常人群应密切监测血小板聚集功能,以防止血栓性疾病发生。
Abstrct OBJECTIVE To explore the effect of dyslipidemia, including hypercholesterolemia and hypertriglyceridema on the platelet distribution width（PDW）. METHODS Height, weight and blood pressure were measured and the history of diseases were investigated. Total cholesterol, triglyceride, fasting blood-glucose, serum uric acid, platelet count（PLT）, mean platelet volume（MPV） and PDW were tested on 3958 middle-aged and elderly people living in the Xiangcheng District of Suzhou. Association between PDW and the indexes of lipid was analyzed by using logistic regression models. RESULTS Mean PDW and the proportion of elevated PDW were higher in dyslipidemia crowd than the control group（P0.05）, and the level of PLT was also higher in the dyslipidemia group than that of the control group（P=0.009）, but the difference of MPV had no statistical significance between the two groups. Moreover, the proportions of hypertriglyceridema and dyslipidemia were higher in the elevated PDW group than the normal PDW group. The results of Logistic regression showed that dyslipidemia and hypertriglyceridema increased the risk of elevated PDW, after adjustment of multiple factors, and the odds ratios（ORs）and 95% confidence intervals were 1.91（1.19~3.06）, 3.22（1.96~5.29）. CONCLUSIONS Dyslipidemia group should closely monitored platelet aggregation function, in order to prevent thrombotic diseases.
出处
《中国初级卫生保健》
2013年第12期116-118,共3页
Chinese Primary Health Care
关键词
血小板分布宽度
血脂异常
甘油三酯
胆固醇
platelet distribution width
dyslipidemia
triglyceride
total cholesterol
