摘要
目的评价梅毒血清学试验检测新生儿先天性梅毒的临床价值。方法对16例患先天性梅毒的新生儿和820例未患先天性梅毒的新生儿血清,用TRUST检测梅毒反应素,ELISA和GICA检测梅毒螺体抗体。结果 TRUST试验对新生儿先天性梅毒的诊断灵敏度、特异度、阳性预测值、阴性预测值、阳性似然比和阴性似然比分别为81.3%、96.2%、29.5%、99.6%、21.4和0.2;ELISA试验为93.8%、98.3%、51.7%、99.9%、55.2和0.1;GICA试验为87.5%、98.4%、51.8%、99.8%、54.6和0.1。结论临床检查新生儿先天性梅毒首选ELISA试验,梅毒血清学试验结果的临床价值需结合临床和随访综合分析。
Objective To evaluate the clinical values of three syphilis serologic tests for neonatal congenital syphilis （NCS）. Methods The syphilis regain was detected by toluidine red unheated serum test（TRUST）, the treponemal antibody was detected by enzyme linked immunosorbent assay （ELISA） and gold immunochromatography assay （GICA）, in the sera from 16 neo- nates with NCS and 820 neonates without NCS. Results The diagnostic sensitivity（ SEN）, diagnostic specificity（ SPE）, positive predictive value （PPV）, negative predictive value （NPV）, positive likelihood ratio （PLR） and negative likelihood ratio （NLR） were 81.3% ,96. 2% ,29. 5% ,99. 6% ,21.4 and 0. 2 by TRUST, respectively. They were 93.8% ,98. 3% ,51.7% ,99. 9% ,55.2 and 0. 1 by ELISA, respectively. They were 87.5% ,98.4% ,51.8% ,99. 8% ,54. 6 and 0. 1 by GICA, respectively. Conclusion The first choice of clinically screening NCS was ELISA.
出处
《四川医学》
CAS
2013年第8期1223-1224,共2页
Sichuan Medical Journal
关键词
梅毒
先天性
酶联免疫吸附试验
金免疫层析试验
甲苯胺红不加热血清试验
syphilis
congenital
enzyme linked immunosorbent assay
goldimmunochromatography assay
toluidine red un-heated serum test
