摘要
目的研究肾移植受者服用大黄制剂对环孢素血药浓度的影响。方法 2008年1月至2012年12月,湖州市第一人民医院10例肾移植受者术后采用环孢素＋吗替麦考酚酯/硫唑嘌呤＋泼尼松三联免疫抑制方案,环孢素用量为5~7 mg·kg-1·d-1,受者术后2~5年因便秘同时服用大黄苏打片（每片含大黄0.15 g,碳酸氢钠0.15 g）,3片/次,3次/d。服用当天及15 d监测受者环孢素血药浓度谷值（C0）、2h后血药浓度峰值（C2）以及肝肾功能,停药15d复查环孢素C0和C2。结果服用大黄苏打片15 d受者环孢素C0、C2均高于服用当天检测值,差异均有统计学意义（t=11.754和12.822,P均〈0.05）。停用大黄苏打片15 d复查环孢素C0、C2均低于服用15 d时检测值,差异均有统计学意义（t=10.020和13.596,P均〈0.05）;与服用当天检测值比较,差异均无统计学差异（t=1.375和0.251,P均〉0.05）。服用大黄苏打片15 d,受者肝肾功能指标与服用当天比较差异均无统计学差异（P均〉0.05）。结论肾移植术后服用环孢素的受者在长期使用含有大黄制剂的药物时,应注意监测环孢素血药浓度,必要时适当调整环孢素用量。
Objective To study the effects of rhubarb preparation on cyclosporine concentration in renal transplant recipients.Methods A total of 10 renal transplant recipients select cyclosporine and mycophenolate mofetil / azathioprine and prednisone triple immunosuppressive regimen（ cyclosporine5-7 mg / kg per day） in Huzhou First People＇ s Hospital from January 2008 to December 2012.The follow-up time was 2-5 years.All patients with constipation took rhubarb soda tablet at the same time（ each containing rhubarb 0.15 g,sodium bicarbonate 0.15 g）,3 tablets each time,3 times a day.Cyclosporine concentration（ C0）,2-hour cyclosporine concentration（ C2）,hepatic and renal functions were monitored after taking rhubarb soda tablet day 0 and 15,respectively.And the indexes were monitored after stopping taking rhubarb soda tablet day 15.Rusrlts The cyclosporine C0,C2were significantly higher after taking rhubarb soda tablet 15 days（ t=11.754 and t=12.822,P〈0.05）.The cyclosporine C0,C2after stopping rhubarb soda tablet 15 days were significantly lower than taking rhubarb soda tablet 15 days（ t=10.020 and t=13.596,P〈0.05）.Comparing with taking rhubarb soda tablet day 0,there were not statistically different in stopping rhubarb soda tablet 15 days（ t=1.375 and t=0.251,P〈0.05）.Comparing with taking rhubarb soda tablet after 15 days,the hepatic and renal functions were not statistically difference in taking rhubarb soda tablet 15 days（ P〈0.05）.Conclusion The renal transplant recipients for long-term taking drugs containing rhubarb preparation should pay attention to monitoring cyclosporine concentration and appropriate adjust the dosage of cyclosporine.
出处
《中华移植杂志（电子版）》
CAS
2013年第3期9-12,共4页
Chinese Journal of Transplantation(Electronic Edition)
关键词
肾移植
大黄
环孢素
血药浓度
Renal transplantation
Rhubarb
Cyclosporine
Blood concentration
