摘要
自从开展器官移植以来,外科手术技术和免疫抑制治疗发生了巨大变化。在过去十年中,排斥反应和移植物失功发生率已明显下降。目前,应用免疫抑制剂的长期并发症已取代排斥反应成为移植治疗的主要挑战。与肾移植和心脏移植相比,肝移植术后急性排斥反应发生率并不高,并且对移植物存活的影响较小,但不合理使用免疫抑制剂也会导致移植失败。如何诱导产生稳定而持久的免疫耐受,适当的免疫调节治疗将是肝移植良好开展的主要保证。本文拟对免疫抑制剂的种类、应用情况和目前的治疗进展进行综述,并探讨肝移植免疫抑制治疗的前景。
Since the organ transplants have been carried out, the surgical techniques and immunosuppressive therapy has changed dramatically. In the past decade, the incidence of rejection and graft dysfunction has decreased significantly. At present, rejection has been replaced by complications of the long-term using immunosuppressant, which has become the main challenge of transplantation. Compared with kidney and heart transplantation, the incidence of acute rejection after liver transplantation is not high, and the impact on graft survival is small. But the unreasonable use of immunosuppressive agents can also lead to transplant failure. How to induce stable and long-lasting immune tolerance, appropriate immunomodulatory therapy will be the main guarantee for liver transplantation. This paper reviewed the species, application and current treatment progress of immunosuppressant, and prospect of immunosuppressive therapy in liver transplantation.
出处
《中华移植杂志（电子版）》
CAS
2013年第3期34-39,共6页
Chinese Journal of Transplantation(Electronic Edition)
关键词
肝移植
排斥
免疫抑制治疗
Liver transplantation
Reject
Immunosuppressive therapy
