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儿童急性淋巴细胞白血病的预后及相关影响因素分析 被引量:11

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摘要 目的:探讨儿童急性淋巴细胞白血病的预后及相关影响因素。方法:回顾性分析接受治疗的急性淋巴细胞白血病患儿的临床资料,依据中华医学会推荐的小儿急性淋巴细胞白血病诊疗建议将患儿分为高危组56例与标危组81例。结果:高危组诱导缓解率为94.64%(53/56),标危组诱导缓解率为91.36%(74/81),差异无统计学意义(P>0.05)。高危组患者诱导缓解后5年无事件生存率显著低于标危组患者,生存率低于标危组,差异均有统计学意义(P<0.025)。Cox多因素分析显示初诊白细胞计数≥50×109/L、泼尼松诱导不敏感、治疗依从性差、治疗中复发及首次诱导缓解失败是导致患儿诱导缓解后5年生存率降低的独立风险因素(P<0.05)。结论:急性淋巴细胞白血病患儿中,高危组患儿诱导缓解后5年生存率及5年无事件生存率均显著低于标危组患儿;应当对具有5年生存率降低独立风险因素的患儿进行密切随访。
作者 刘景珍
出处 《中国妇幼保健》 CAS 北大核心 2014年第1期70-72,共3页 Maternal and Child Health Care of China
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