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儿童矮小症67例病因和治疗分析 被引量:14

Etiology and treatment of 67 children with short stature
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摘要 目的探讨儿童矮小症的病因与治疗特点,为临床诊断治疗提供参考依据。方法对67例儿童矮小症患儿的临床资料进行分析,并使用重组人生长激素(rh—GH)和其他相关治疗。结果67例矮小症儿童中,生长激素(GH)缺乏性矮小23例,特发性矮小21例,家族性矮小9例,体质性青春发育延迟4例,宫内发育迟缓3例,Turner综合征、甲状腺功能减退、21-三体综合征各2例,先天性软骨发育不良1例。rh—GH对生长激素缺乏症(GHD)疗效显著,对特发性矮小、家族性矮小、宫内发育迟缓效果满意,非GH缺乏甲状腺功能低下者予以甲状腺素片治疗,生长增速。结论矮小原因很多,及时发现病因,寻求最佳治疗手段非常重要。 Objective To study the etiological factors and treatment feature of children with short stature, and provide reference for clinical diagnosis and treatment. Methods The clinical data of 67 children with short stature were analyzed, and they respectively adopted reorganization human growth hormone (rhGH) and comprehensive treatment. Results Among the 67 cases of children with short stature, growth hormone deficiency(GHD) in 23 cases, idiopathic short stature in 21 cases, familial short stature in 9 cases, constitutional delay of growth and puberty in 4 cases, 3 cases for intrauterine growth retardation(IUGR) , 2 cases for Turner syndrome, 2 cases for hypothyroidism, 2 cases for Down' s syndrome, 1 case for Congenital cartilage dysplasia. Rh-GH was effective on treatment of GHD, ISS, familial short stature and IUGR was better. The same curative effect could be achieved in hypothyroidism and non-GHD cases after treatment with thyroid tablets. Conclusions According to the pathogeny, selecting correct treatments is the key to treat the short stature children.
出处 《中国实用医刊》 2014年第2期26-28,共3页 Chinese Journal of Practical Medicine
关键词 儿童 矮小症 病因 治疗 Children Short stature Etiology Treatment
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  • 1刘戈力.特发性身材矮小[J].中国实用儿科杂志,2005,20(8):454-456. 被引量:10
  • 2潘桂梅,董青,张颖,陈志红,李堂.国产重组人生长激素治疗特发性矮身材患儿的疗效[J].实用儿科临床杂志,2007,22(8):591-592. 被引量:9
  • 3Wit JM,Clayton PE,Rogol AD,et al.Idiopathic short stature:Definition,epidemiology,and diagnostic evaluation.Growth Horm IGF Res,2008,18:89-110.
  • 4Rosenfeld,RG.The molecular basis of idiopathic short stature.Growth Hormone and IGF Research,2005,15(Suppl A):S3-S5.
  • 5Rappald GA,Fukami M,Niesler B,et al.Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature.J Clin Endocrinol Metab,2002,87:1402-1406.
  • 6Toyoshima MT,Castroneves LA,Costalonga EF,et al.Exon 3-deleted genotype of growth hormone receptor (GHRd3) positively influences IGF-1 increase at generation test in children with idiopathic short stature.Clin Endoorinol,2007,67:500-504.
  • 7Kamp CA,Mul D,Waelkens J J,et al.A randomized controlled trial of three years growth hormone and gonedotropin-releasing hormone agonist treatment in children with idiopathic short stature and intrauterine growth retardation.J Clin Endocrinol Metab,2001,86:2969-2975.
  • 8Hero M,Makitie O,Kroger H,et al.Impact of aromatase inhibitor therapy on bone turnover,cortical bone growth and vertebral morpholngy in pre-and peripubertal boys with idiopathic short stature.Horm Res,2009,71:290-297.
  • 9Rosenhloom AL.The role of recombinant insulin-like growth factar 1 in the treatment of the short child.Curr Opin Pediatri,2007,19:458-464.
  • 10Wit JM.Growth hormone therapy.Rest Prac Res Clin Endocrinol Metnh,2002,16:483-503.

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