摘要
目的明确维持性血液透析患者高尿酸血症的发生率及其与动脉粥样硬化的关系。方法选择62例维持性血液透析患者,检测其透析前的血尿酸、C反应蛋白、总胆固醇、甘油三酯水平,并行颈动脉血管彩超检查。比较高尿酸血症组与血尿酸正常组患者年龄、性别、透析时间、是否糖尿病、BMI、透析前血压、C反应蛋白、总胆固醇、甘油三酯、颈动脉内—中膜厚度(IMT)的差异;同时将血尿酸水平与C反应蛋白、血压、IMT进行相关分析。结果 MHD患者高尿酸血症发生率为54.8%;颈动脉粥样硬化的发生率为46.8%;高尿酸血症组患者舒张压、甘油三酯、C反应蛋白、IMT的水平均显著高于尿酸正常组,差异有显著性(P<0.05),而两组在年龄、性别、透析时间、是否糖尿病、BMI、收缩压、总胆固醇方面无显著性差异(P>0.05)。经单因素相关分析结果表明血尿酸与C反应蛋白、舒张压、IMT呈正相关性。结论维持性血液透析患者的高尿酸血症及动脉粥样硬化发生率高,高尿酸血症与动脉粥样硬化关系密切,其病理生理学基础可能是高尿酸所致的体内微炎症状态。为减少维持性血液透析患者的心脑血管并发症需重视高尿酸血症的防治。
Objective To investigate the incidence of hyperuricemia in maintenance hemodialysis （MHD） patients and the relationship between hyperuricemia and atherosclerosis. Methods A total of 62 MHD patients were simultaneously collected in the study. Serum uric acid, C reactive protein （CRP）, cholesterol and triglyceride were measured before hemodialysis in these patients, and carotid ultrasonography was performed. Then we compared the differences in age, gender, dialysis time, diabetes, BMI, blood pressure before dialysis, CRP, cholesterol, triglyceride and the carotid intima-media thickness （IMT） between patients with and without hyperuricemia. Meanwhile, correlation analysis concerning the serum uric acid and CRP, blood pressure, IMT was conducted. Results The incidences of hyperuricemia and carotid atherosclerosis of MHD patients were 54.8% and 46.8% respectively. The diastolic blood pressure （DBP）, triglyceride, CRP and IMT of patients with hyperuricemia were higher than patients without hyperuricemia （P〈0.05）. But there was no statistic difference in age, gender, dialysis time, diabetes, BMI, systolic blood pressure and cholesterol between these two groups （P〉0.05）. Correlation analysis showed that serum uric acid was positively correlated with CRP, diastolic blood pressure and IMT. Conclution It is shown by our present study that there were high incidences of hyperuricemia and atherosclerosis in MHD patients. It is suggested that hyperuricemia is significiently related with atherosclerosis. The micro-inflammatory state caused by hyperuricemia might be it＇s pathophysiologic basis. So we should pay more attention to preventing and treating hyperuricemia in order to reducing cardio-cerebrovascular complications of MHD patients.
出处
《解剖学研究》
CAS
2013年第6期443-445,共3页
Anatomy Research
