摘要
目的:比较不同方法灌注5-FU后,犬舌及颌下淋巴结组织内的药物浓度。方法 :16只健康家犬称重后随机分为A组(舌动脉给药)和B组(股静脉给药)。分别行经舌动脉及股静脉持续24 h灌注5-FU。在12、24 h采集2组灌注侧舌体组织及下颌下淋巴结。反相高效液相色谱法(RP-HPLC)检测以上采集组织标本中5-FU含量。结果:全麻状态下,犬能耐受24 h舌动脉持续灌注5-FU并保持生命体征平稳。舌动脉灌注组舌体组织及颌下淋巴结内5-FU浓度,明显高于股静脉给药组。结论:5-FU舌动脉持续灌注后,舌及下颌下淋巴结的药物浓度均明显高于股静脉持续灌注。
Objective： To study concentrations of 5-FU in tongue and submandibular lymph nodes by using different infusion methods. Methods： Sixteen dogs were divided randomly into two groups, Group A was used intra-lingual arterial drug infusion and Group B was femoral vein drug infusion. 5-FU was continuously infused to lingual artery by superficial temporal artery retrograde intubation and femoral vein by micro-infusion pump, respectively. The ipsilateral tongue and submandibular lymphatic nodes were harvested at 12 h, 24 h. The concentration of 5-FU in tissues at different time point were determined by PR-HPLC. Results： The dogs could withstand 24 h continuous 5-FU infusion through lingual artery under general anesthesia and maintain stable vital signs. The drug concentration in ipsilateral tongue and submandibular lymphatic nodes by intra-lingual arterial infusion was much higher than that of femoral vein infusion. Conclusion： 5FU concentrations in submandibular lymph nodes and tongue using continuous lingual artery infusion found to be much higher than that of femoral vein infusion.
出处
《口腔颌面外科杂志》
CAS
2013年第6期424-426,共3页
Journal of Oral and Maxillofacial Surgery
基金
2010遵义医学院硕士启动资金资助项目(黔科合J字LKZ[2011]23号)
2012遵义医学院附属口腔医院资助项目
关键词
舌动脉持续灌注
股静脉持续灌注
5-FU
舌体组织
颌下淋巴结
犬
continuous lingual artery infusion
continuous femoral vein infusion
5-FU
tongue tissue
submandibular lymph nodes
dogs
