摘要
目的探讨乙型肝炎（HB）抗病毒治疗停药后复发与血清HBVDNA水平的相关性。方法选取180例接受阿德福韦酯治疗的HB患者，检测患者治疗前及治疗4周后血清HBVDNA水平。结果HBeAg（＋）时，治疗前HBVDNA水平〉10±7copyies／mL复发率是56％，10±6～10±7copies／mL复发率是36％，〈10。copies／mL复发率是10％，HBVDNA水平〉10^7copies／mL停药复发率最高，〈10^6copies／mL最低。治疗4周后，HBVDNA水平〈10±3copies／mL复发率是18％，较基线下降幅度≥3lgcopies／mL者复发率是20％，较基线下降幅度2lgcopies／mL者复发率是21％，较基线下降幅度1lgcopies／mL者复发率是37％，HBVDNA水平〈10±3copies／mL复发率最低，较基线下降幅度1lgcopies／mL者复发率最高。HBeAg（-）时，治疗前HBVDNA水平〉10^7copies／mL复发率是27％，10^6～10^7copies／mL复发率是11％，〈10^6copies／mL复发率是7％，HBVDNA水平〉10。copies／mL停药复发率最高。治疗4周后，HBVDNA水平〈10^3copies／mL复发率是6％，较基线下降幅度≥3lgcopies／mL者复发率是10％，较基线下降幅度2lgcopies／mL者复发率是11％，较基线下降幅度llgcopies／mL者复发率是63％，HBVDNA水平〈10^3copies／mL复发率最低。较基线下降幅度1lgcopies／mL者复发率最高。结论HB患者抗病毒治疗停药后复发和患者治疗前的血清HBVDNA水平、治疗早期HBVDNA水平及血清HBVDNA水平降幅存在相关性。
Objective It is to approach the correlation between recurrence after antiviral treatment of hepatiiis B stopped and serum HBV DNA level. Methods 180 hepatitis B patients treated with Adefovir Dipivoxil were selected, the serum HBV DNA levels of them were detected before treatment and 4 weeks after treatment. Results As HBeAg （ ＋ ） , before treatment, the recurrence rate was 56 % for HBV DNA level 〉 10^7 copies/mL, 36 % for HBV DNA levels from 106 to 10^7 copies/mL, and 10 % for HBV DNA levels 〈 106 eopies/mL, the recurrence rate of HBV DNA levels 〉 10^7 eopies/mL was highest, 〈 10^6 copies/mL was lowest. After 4 weeks treatment, the recurrence rate was 18 % for HBV DNA level 〈 10^3 copies/mL, 20% for down≥3 lgcopies/mL compared with baseline, 21% for drop 2 lgcopies/mL, 37% for drop 1 lgcopies/mL, the re- currence rate of HBV DNA level 〈 103 copies/mL was lowest, drop 1 lgcopies/mL was highest. As HBeAg （ - ） , before treatment, the recurrence rate was 27% for HBV DNA level 〉 10^7 copies/mL, 11% for HBV DNA level from 10^6 to 10^7 cop- ies/mL, and 7% for HBV DNA level 〈 106 copies/mL, the recurrence rate of HBV DNA level 〉 10^7 eopies/mL was highest. after 4 weeks treatment, the recurrence rate was 6% for HBV DNA level 〈 103 copies/mL, 10% for Down ≥3 lgcopies/mL compared with baseline, 11% for drop 2 lgeopies/mL, 23% for 1 lgcopies/mL, the recurrence rate HBV DNA level 〈 10^3 eopies/mL was lowest, drop 1 lgcopies/mL was highest. Conclusion Hepatitis B recurrence after discontinuation of antiviral therapy in patients is correlated with the serum HBV DNA levels betbre treatment, early HBV DNA level after treatment and decreasing amplitude of the serum HBV DNA levels after treatment.
出处
《现代中西医结合杂志》
CAS
2014年第3期248-250,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
