摘要
本文通过5-(α-萘)-2H-四唑-2-乙酰肼(Ⅰ)与芳酰基异硫氰酸酯缩合制得16种新的1-[5-(α-萘)-2H-四唑-2-乙酰基]-4-芳酰基胺基硫脲(Ⅱ),(Ⅲ)在碱性催化条件下环化为3-[5-(α-萘)-2H-四唑-2-亚甲基]-4-芳酰基-1,2,4-三唑啉-5-硫酮(Ⅲ),化合物的结构经元素分析,IR、~1H NMR和MS鉴定,对化合物(Ⅲ)的质谱裂解进行分析,解释了化合物(Ⅱ)的环化方向,经初步筛选,发现个别化合物对小麦胚芽生长有促进作用。
A series of new 1-[5-(α-naphthyl)-2H-tetrazol-2-acetyl]-4-aroylthiosemicarbazides(Ⅱ) weresynthesized by condensation of aroylisothiocyanate with 5- ( α- naphthyl- 2H- tetrazol- 2-acetylhydrazine(Ⅰ) in absolute acetonitrile. Some of 3-[5-(α-naphthyl)-2H-tetrazol-2-methylene]-4-aroyl-1 ,2,4-triazoline-5-thione(Ⅲ) were prepared by the cyclization of compounds(Ⅱ) under the catalysis of 1 mol/L K2CO3 solution. The structures of all compounds prepared were characterized by elemental analysis, IR and 1H NMR. The regioselectivity of the cyclization of compounds (Ⅱ ) was rationalized with the fragments of mass spectra of compounds ( Ⅲ ).Preliminary pharmacological examinations show that the new compounds (Ⅱ) and (Ⅲ) possess some promoting, or inhibiting activity on growth of plumule of wheat.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1991年第10期1326-1330,共5页
Chemical Journal of Chinese Universities
关键词
酰胺基硫脲
杂环衍生物
生物活性
Acylthiosemicarbazides, Tetrazole, Heterocyclic 1,2,4- triazoline- 5- thione, Biological activity
