摘要
目的评价常频机械通气联合西地那非治疗新生儿持续肺动脉高压的疗效及安全性。方法48例持续肺动脉高压新生儿随机分为2组，对照组23例给予常频通气等常规治疗；治疗组25例在对照组治疗基础上给予枸橼酸西地那非片0．5～2．0mg／（kg·次）鼻饲，1次／6h，直至撤机。结果治疗组肺动脉压力和肺动脉／体循环收缩压比值在治疗后逐步下降（P〈0．05）；治疗后2组pa（O2）和氧合指数与治疗前比较差异有统计学意义（P〈0．05）；2组上机时间、氧暴露时间及住院时间比较差异均有统计学意义（P〈0．05），病死率、气胸和颅内出血发生率比较差异无统计学意义（P〉0．05）。结论常频通气联合西地那非治疗新生儿持续肺动脉高压疗效确切，且不增加主要并发症的发生率。
Objective To evaluate the effect and safety of conventional ventilation combined with sildenafil in the treatment of persistent pulmonary hypertension of newborn. Methods Forty-eight newborns with persistent pulmonary hypertension were randomly divided into sildenafil group （n = 25） and control group （n = 23）. Control group received routine therapy including conventional ventilation, and sildenafil group received sildenafil （0.5 to 2.0 mg/kg） by nasal feeding, once per 6 hours besides the therapy in control group. Results The pulmonary artery pressure, ratio of pulmonary artery pressure to systolic blood pressure decreased gradually in sildenafil group after treatment compared with before treatment （P〈O. 05）. There were significant differences in pa（O2 ） and oxygenation indexes in both two groups after treatment compared with before treatment （P〈0.05）. There were significant differences in ventilation time, exposure time to oxygen and duration of hospitalization between two groups （P〈O. 05）, and no significant difference in fatality rate and incidence rates of pneumothorax and intracranial hemorrhages between two groups （P 〉 0.05 ）. Conclusions Conventional ventilation combined with sildenafil can effectively improve the result without increasing complications in persistent pulmonary hypertension of newborns.
出处
《中华实用诊断与治疗杂志》
2014年第1期75-76,共2页
Journal of Chinese Practical Diagnosis and Therapy
关键词
常频通气
西地那非
新生儿
持续肺动脉高压
Conventional ventilation
sildenafil
newborn
persistent pulmonary hypertension
