摘要
目的:探讨甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TpoAb)、促甲状腺素受体抗体(TRAb)水平在桥本甲状腺炎(HT)、Graves病(GD)中的改变及其临床意义。方法:240例甲状腺功能亢进(甲亢)患者中,Ⅰ组HT 112例,Ⅱ组GD 66例,Ⅲ组非自身免疫性甲亢62例,Ⅳ组为健康体检者80名。以电化学发光免疫分析法检测4组血清中TGAb、TpoAb、TRAb水平。结果:Ⅰ组患者血清TGAb、TpoAb和TRAb均显著高于Ⅱ组、Ⅲ组和Ⅳ组(P<0.01);Ⅱ组患者血清TGAb、TpoAb和TRAb亦均显著高于Ⅲ组和Ⅳ组(P<0.01)。Ⅰ组患者TGAb阳性率90.17%,TpoAb阳性率100.00%,TRAb阳性率6.25%;Ⅱ组患者TGAb阳性率30.30%,TpoAb阳性率70.21%,TRAb阳性率90.90%。结论:联合检测TGAb、TpoAb、TRAb对诊断及鉴别诊断HT和GD等自身免疫性甲状腺疾病具有重要意义,TRAb升高对GD特别有诊断价值。
Objective： To study the changes of serum thyroglobulin antibody （TGAb）, thyroid peroxidase antibody （TpoAb） and thyroid hormone receptor antibody（TRAb） levels in Hashimoto＇s thyroiditis（HT） and Graves disease（GD） ,and evaluate their clinical values. Methods：Two hundred and forty cases of hyperthyroidism were selected,including 112 cases of HT in group Ⅰ ,66 cases of GD in group Ⅱ ,62 cases of non autoimmune hyperthyroidism in group Ⅲ, and 80 healthy persons in group Ⅳ. Serum TGAb,TpoAb and TRAb levels were detected by electrochemiluminescence immunoassay in four groups. Results： The serum TGAb, TpoAb and TRAb levels from the patients in Group I were significantly higher than in group Ⅱ, Ⅲ and Ⅳ （ P 〈 0.01 ） ; the serum TGAb, TpoAb and TRAb levels in group Ⅱ were also significantly higher than those in group Ⅲ and Ⅳ （ P 〈 0.01 ）. In group Ⅰ , the positive rate of TGAb was 90.17% ,the positive rate of TpoAb was 100.00% ,the positive rate of TRAb was 6.25% ;in group Ⅱ ,the positive rate of TGAb was 30.30%, the positive rate of TpoAb was 70.21%, the positive rate of TRAb was 90.90%. Conclusions ： Detection of serum TGAb, TpoAb,TRAb level plays an important role in the diagnosis and differential diagnosis of HT and GD in autoimmune thyroid disease,the elevation of TRAb plays special diagnostic value for GD.
出处
《蚌埠医学院学报》
CAS
2013年第12期1652-1653,共2页
Journal of Bengbu Medical College
