摘要
目的 探讨功能性消化不良与抑郁症的关系及其神经内分泌机制。方法 用 SDS问卷调查法调查 FD患者组与正常人组抑郁症的发生率 ,并用酶联法和放免法测定血清褪黑素 (MT)和血浆胃动素水平。结果 FD患者抑郁症发生率比正常人组高 ,分别为 5 7.5 %和 17.4%。伴有抑郁的 FD患者组血清 MT和血浆胃动素水平比不伴有抑郁的 FD患者组及正常参照组低 (P <0 .0 1) ,伴有抑郁的 FD患者组 MT38.5± 17.2 ,胃动素 16 3.5 2± 37.2 ;不伴有抑郁的 FD患者组 MT6 9.5 2±2 5 .72 ,胃动素 2 98.2 1± 49.5 1;正常参照组 MT(77.42± 2 8.41) ng/ L,胃动素 (30 2 .31± 5 7.2 1) ng/ L。结论 FD与抑郁症有明显联系 ,血清 MT和血浆胃动素水平下降与伴有抑郁的
Objective To explore the relationship between FD and depression and nuroendocrinologic mechanism.Methods We administered the SDS questionaire to patients with FD and normal group.The contents of serum MT and plasma motilin were assayed with ELISA and RIA.Result The rate of depression in patients with FD was higher than normal group,which were 57 5% and 17 4%,respectively.The levels of serum MT and plasma motilin in FD patients with depression were lower than in the patients without depression and normal group(P<0 01),which were MT 38 5±17 2,motilin 163 52±37 2 in the group of FD patients with depression;MT 69 52±25 72,motilin 298 21±49 51 in the group of FD patients without depression;MT(77 42±28 41)ng/L,motilin(302 31±57 21)ng/L in normal group.Conclusion FD was related to depression.The lower contents of serum MT and plasma motilin was closely related to onset of FD with depression.
出处
《中国行为医学科学》
CSCD
2000年第5期332-333,共2页
Chinese Journal of Behavioral Medical Science
基金
安徽省教委自然科学基金资助课题!(编号 :98JL0 46 )
