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沙鼠前脑缺血再灌注损伤后脑组织HSP27和IGF-1的表达变化 被引量：1

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摘要 目的通过观察脑组织中热休克蛋白(HSP27)和胰岛素样生长因子-1(IGF-1)在沙鼠前脑缺血再灌注损伤后的表达变化。方法对沙鼠予以夹闭双侧颈总动脉并再通造成脑缺血再灌注模型。观察沙鼠前脑组织HE染色的病理变化,观察免疫组织化学染色HSP27与IGF-1的表达情况。结果 HE染色:脑缺血再灌注组可见胶质细胞水肿、肥大、增生、神经元坏死等情况。免疫组化染色:与对照组及假手术组相比,脑缺血再灌注组HSP27和IGF-1的表达于6h开始上调,3d达高峰,7d时仍偏高。结论缺血再灌注的沙鼠脑组织中HSP27与IGF-1表达均升高并可能减轻缺血再灌注所导致的脑损伤。
作者 程坤 胡治平
机构地区 长治医学院附属和平医院 中南大学湘雅二医院
出处 《中西医结合心脑血管病杂志》 2013年第12期1499-1500,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 脑缺血再灌注损伤 脑组织 热休克蛋白 胰岛素样生长因子-1
分类号 R743 [医药卫生—神经病学与精神病学] R255.2 [医药卫生—中医内科学]
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参考文献11

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二级参考文献48

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中西医结合心脑血管病杂志
2013年 第12期

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