摘要
目的观察血管性认知功能障碍患者的事件相关电位特性。方法以非认知功能障碍正常对照组、非痴呆型血管认知功能障碍组和血管性痴呆组进行19通道的事件相关电位分析,自动记录反应时间和反应按键的正误,应用重复测量方差分析和配对检验进行比较。结果血管性痴呆组的反应时间(F=54.18,P<0.001)和按键正确率(F=40.23,P<0.001)较正常对照组、非痴呆型血管认知功能障碍组有显著差异,正常对照组的行为绩效反应时间[(325.16±69.39)ms]、正确率[(97.5±1.6)%]优于非痴呆型血管认知功能障碍组[(384.58±76.25)ms,(88.2±8.9)%]和血管性痴呆组[(472.65±89.30)ms,(57.8±7.8)%],后2组行为绩效比较亦存在显著性差异。ERP提示非痴呆型血管认知功能障碍和血管性痴呆的P300、N400潜伏期较正常对照组明显延长,3组潜伏期及波幅比较差异有统计学意义(P<0.05)。结论事件相关电位的P300、N400成分作为一种客观、量化的电生理指标,可用于早期识别脑卒中血管性认知功能障,为非痴呆型血管认知功能障碍的诊断和评估预后提供了重要的客观辅助手段。
Objective To investigate the characteristic of event-related potentials in patients with vascular cognitive impairment. Methods Thirteen participants joined auditory event-related potential. Ten patients with VaD and ten patients with VCIND were selected according to diagnostic standard of VCI and Montreal cognitive assessment, and ten subjects with normal cognition as control group. Results VaD groups were significantly different with the other groups in reaction time IF （2, 26） =54.18, P〈0.001] and the accuracy IF（2, 26）=40.23, P〈0.001]. The performance of the control group [（325.16±69. 39） ms, （97.5±1.6）%] were significantly better than either the VCIND groups[（384. 58± 76.25）ms, （88.2± 8.9）%] and the VaD groups[（472.65±89.30）ms, （57.8±7.8）%]. Conclusion with the control group, the latency of P300, N400 in VaD groups and VCIND groups were significantly prolonged （P〈0.05）. Conclusion ERP-P300 and N400 has early diagnosis value for vascular cognitive impairment.
出处
《中国实用神经疾病杂志》
2013年第23期37-38,共2页
Chinese Journal of Practical Nervous Diseases
关键词
血管性认知功能障碍
血管性痴呆
事件相关电位
Vascular cognitive impairments Vascular dementias Event-related potentials
