摘要
延胡索是常用传统中药之一,主要化学成分为原小檗碱类和阿朴啡类生物碱。该文概述延胡索所含生物碱成分的研究,分析其结构类型及新的定性、定量方法;分析其生物转化、吸收、分布、代谢、排泄、药代动力学、药物相互作用等特点,为确定延胡索的药效物质基础提供科学依据。
Corydalis Rhizoma, the dried tuber of Corydalis yanhusuo （Papaveraceae） distributed traditionally mainly in south- eastern and now cultivated in northwestern and other district in China, is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain, abdominal pain, pain due to injury, and promote blood circulation. Its main chemical constituents were alkaloids, which were divided into the two types of protoberberines and aporphines. Among them, some al- kaloids were found to elicit profound effects on the dopaminergic system in the central nervous system, which plays an important role in regulating nociception. In this article, the chemical composition and structure-types, new methods of qualitative and quantitative analysis as well as characteristics of biotransformation, absorption, distribution, metabolism, excretion, pharmacokinetic, and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第1期20-27,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金重点项目(30830118)
国家"十二五"科技支撑计划项目(2011BAI07B08)
关键词
延胡索
生物碱
药效物质基础
dried tuber of Corydalis yanhusuo
alkaloid
bioactive material base
