摘要
目的探讨新生儿缺血缺氧性脑病(HIE)患儿血清中S-100B蛋白浓度对诊断及预后的影响。方法选取HIE患儿50例作为HIE组,正常新生儿50例作为对照组,两组新生儿全部留取24 h静脉血,通过双抗体夹心法测定血清中S-100B蛋白浓度。HIE组与对照组随访6个月后进行发育筛查(DST)测试并根据发育商(DQ)记录正常、可疑及异常三种情况例数。结果 HIE组的血清S-100B蛋白浓度明显高于对照组,差异有统计学意义(P<0.05)。HIE组中重度患儿血清S-100B蛋白浓度最高,轻度次之,对照组最低,差异有统计学意义(P<0.05)。HIE组DQ可疑及异常两种情况的例数均明显高于对照组,差异有统计学意义(P<0.05)。两组中DQ正常的新生儿血清S-100B蛋白浓度明显低于DQ可疑/异常的新生儿,差异有统计学意义(P<0.05)。结论新生儿血清中S-100B蛋白浓度可作为HIE诊断的一项客观指标,并且对HIE预后情况的预测有重要的临床应用价值。
Objective To investigate the role of serum S - 100 -b protein concentration effects on neonatal HIE diagnosis and prognosis in children with neonatal hypoxie ischemia eneephalopathy （HIE）. Methods 50 HIE eases and 50 normal newborn were included into this stud- y. 50 normal newborn were considered as control group. S - 100 - b protein in serum concentrations in two groups of newborn were detected by double antibody clamp method. HIE group and eontrnl group were followed up for 6 months after developmental screening test （DST） and accord- ing to the normal developmental quotient （DQ） records, suspicious cases and three kinds of abnormal situation. Results HIE group concentration of serum S - 100 -b protein is significantly higher than that of the control group. The difference was statistically significant （ P 〈0.05）. Moder- ately severe HIE group showed the highest concentration of serum S - 100 - b protein, mild times, the lowest in the control group. The difference was statistically significant （ P 〈 0.05 ）. HIE group DQ suspicious and abnormal eases of two cases were significantly higher than that of control group. The difference was statistically significant （ P 〈 0.05 ）. DQ in the two groups of normal newborns serum S - 100 - b protein concentration was significantly lower than the DQ suspicious/abnormal newborns. The difference was statistically significant （ P 〈 0.05 ）. Conclusion New- born S - 100 - b protein in serum concentration can be considered as an objective index of HIE diagnosis, The S - 100 - b protein can predict HIE prognosis and have important clinical value.
出处
《临床和实验医学杂志》
2014年第1期55-57,共3页
Journal of Clinical and Experimental Medicine
