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DNA甲基化转移酶与乳腺癌相关性的研究进展 被引量：1

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摘要 乳腺癌是一种严重威胁女性健康的疾病,我国乳腺癌发病率呈逐年上升趋势。近期的大量研究评估了表观遗传学异常在乳腺癌发生发展中的作用。基因甲基化是乳腺癌发病机制研究最为热点的一种表观遗传学机制,而DNA甲基化转移酶（DNMT）作为调控基因甲基化的主要方式,在乳腺癌的发生发展中起到重要的作用。研究DNMT能为阐述乳腺癌的发病原因提供一个新的视角,筛查DNMT可以在临床确诊乳腺癌之前，提前预估出人们患乳腺癌的风险，指导患者的用药，并就患者预后进行评估。DNMT的研究是乳腺癌临床治疗的新机遇，现就DNMT与乳腺癌的相关性研究进展综述如下。
作者 吴琼 邵国 张培礼
机构地区 包头医学院 包头市肿瘤医院
出处 《包头医学院学报》 CAS 2013年第6期134-136,共3页 Journal of Baotou Medical College
关键词 甲基化转移酶 乳腺癌 癌相关性 DNA 基因甲基化 临床治疗 遗传学异常 遗传学机制
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献17

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同被引文献24

  • 1蒋曹德,邓昌彦,熊远著.猪个体DNA甲基化百分差异与胴体性状的关系[J].农业生物技术学报,2005,13(2):179-185. 被引量：17
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包头医学院学报
2013年 第6期

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