摘要
目的:探讨早期糖尿病肾病(DN)患者炎症细胞因子、肾血管内皮功能的变化及丹参多酚酸盐干预治疗作用。方法:选择早期DN患者64例,分为常规治疗组、丹参多酚酸盐治疗组,健康对照组30例,检测DN患者治疗前后及健康受检者外周血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、血清可溶性细胞间黏附分子-1(sICAM-1)、血内皮素-1(ET-1)水平,同时利用超声检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD)。结果:早期DN患者组hs-CRP,TNF-α,IL-6,ICAM-1及ET-1均高于对照组(P<0.05);早期DN患者FMD较对照组降低(P<0.05);丹参多酚酸盐组治疗后外周血hs-CRP,sICAM-1,ET-1,TNF-α,IL-6[hs-CRP(9.24±2.16)mg·L-1,sICAM-1(257.72±16.32)μg·L-1,ET-1(103.78±12.21)ng·L-1,TNF-α(14.62±7.23)ng·L-1,IL-6(16.12±5.68)ng·L-1]较常规治疗组[(14.58±3.32)mg·L-1,(567.43±16.24)μg·L-1,(258.5±9.78)ng·L-1,(36.72±6.23)ng·L-1,(34.62±7.01)ng·L-1]下降更明显,FMD升高更明显[(10.12±3.27)%vs(7.17±0.32)%],且差异有统计学意义(P<0.05)。结论:丹参多酚酸盐能有效的降低早期DN患者炎症反应,并改善肾血管内皮功能。
Objective： To investigate the changes of inflammatory cytokines, renal vascular endothelial function in early diabetic nephropathy and the effect of salvianolate on intervention.Method： Sixty-four patients with early diabetic nephropathy were selected and randomly divided into 2 groups（routine group and salvianolate group）.routine group was treated with insulin;the salvianolate group was treated with 200 mg·d-1 salvianolate combined with insulin. 30 healthy as control group.The endothelium-dependent flow-mediated dilatation（FMD）of brachial artery was determined with ultrasound,and the levels of soluble intercellular adhesion molecule-1（sICAM-1）,endothelin-1（ET-1）, interleukin-6（IL-6）,tumor necrosis factor（TNF-α）and High-sensitivity C-reactive protein（hs-CRP）were measured respectively before and after treatment. Result： All patients with early diabetic nephropathy showed that the hs-CRP,TNF-α,IL-6,ICAM-1 and ET-1 was higher than that of the controlled group（P〈0.05）, the FMD were lower than controlled group（P〈0.05）. After treatment the hs-CRP,TNF-α,IL-6,ICAM-1 and ET-1 in the salvianolate group[hs-CRP（9.24±2.16）mg·L-1, sICAM-1（257.72±16.32） μg·L-1, ET-1（103.78±12.21） ng·L-1,TNF-α（14.62±7.23） ng·L-1,IL-6（16.12±5.68） ng·L-1]was decreased more significantly than routine group[（14.58±3.32）mg·L-1, （567.43±16.24） μg·L-1, （258.5±9.78） ng·L-1, （36.72±6.23）ng·L-1, （34.62±7.01）ng·L-1]（P〈0.05）. After treatment the FMD in the salvianolate group was increased more significantly than routine group[（10.12±3.27）% vs（7.17±0.32）%]（P〈0.05）. Conclusion： The salvianolate can effectively reduce the bodys inflammationrecovery and recovery renal vascular endothelial function with early diabetic nephropathy.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第2期184-187,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西科学研究与技术开发计划项目(桂科攻0816004-26)
关键词
糖尿病肾病
内皮功能障碍
炎症
丹参多酚酸盐
diabetic nephropathies
endothelial dysfunction
inflammation
salvianolate
