摘要
孕烷受体(PXR)是核受体亚家族的成员之一,其对多种体内药物处置的相关基因起重要的调节作用。诸多药物可通过PXR调节代谢酶与药物转运体的表达,影响其他药物的体内过程。PXR已成为药理学、生理学等研究的热点。本文对其对代谢酶和转运体的调节及其重要作用等研究进展作一综述。
Pregnane X receptor （PXR） is a member of nuclear receptor subfamily. PXR play an important role in regulating the expression of multiple genes that are involved in the drugs dispose in the body. Multi- ple drugs could regulate the expression of CYP and transporters, and af- fect the process of drugs in the body. PXR has become the hot spots of pharmacology, physiology and other scientific research. In this paper, we will make a review on its regulations of metabolic enzymes and transport- ers, and its important role of research.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第1期66-69,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金(青年)资助项目(81202583)
江西省教育厅青年基金资助项目(GJJ12145)
江西省卫生厅中医药科研计划课题基金资助项目(2012A137)
关键词
孕烷受体
代谢酶
药物转运体
pregnane X receptor
metabolic enzyme
drug transporter
