摘要
目的比较吸入糖皮质激素(ICS)联合小剂量茶碱与联合白三烯调节剂治疗5岁以下儿童哮喘的临床效果。方法将90例中度持续性哮喘患者按照随机原则分为ICS+茶碱组和ICS+孟鲁司特钠组,每组各45例。两组均常规吸入丙酸氟替卡松,ICS+茶碱组加用口服缓释茶碱片6 mg/(kg·d),分两次服;ICS+孟鲁司特组加用口服孟鲁司特钠,1次/d,4 mg/次,两组疗程均为6个月。结果治疗3个月及6个月后,两组的日间症状评分、夜间症状评分、ACT评分与治疗前比较,差异有统计学意义(P<0.05),两组的上述指标比较,差异无统计学意义(P>0.05)。结论吸入丙酸氟替卡松联合小剂量茶碱与联合白三烯调节剂治疗5岁以下儿童哮喘的效果相当。
Objective to compare the effect of inhaled corticosteroids combined with small-dose theophylline and in- haled corticosteroids combined with leukotriene modifiers treating asthma children under age 5. Methods A total of 90 patients with moderate persistent asthma were randomly divided into the ICS ＋ theophylline group （n=45） and the ICS ＋ montelukast sodium group （n=45）.The two groups were routinely inhaled fluticasone propionate,while the ICS ＋ theophylline group was given oral sustained-release theophylline tablets,6 mg/kg per day,twice a day;the ICS ＋ montelukast sodium group was given oral montelukast,once a day,4 mg each time.Two groups were both treated for 6 months. Results After 3 months and 6 months treatment,the asthma symptoms score in the morning and at night,the ACT score of the two groups had a statistical difference compared with before treatment （P〈0.05）.and there was no statistical difference of above-mentioned indicators in the two groups （P〉0.05）. Conclusion The effect of inhaled fluticasone propionate com- bined with small-dose theophylline or leukotriene modifiers treating asthma in children under age 5 are nearly the same.
出处
《中国当代医药》
2014年第2期103-106,共4页
China Modern Medicine
关键词
哮喘
糖皮质激素类
茶碱
孟鲁司特钠
Asthma
Glucocorticoids
Theophylline
Montelukast sodium
